The sodium/glucose cotransporter 2 (SGLT2) is a protein that in humans is encoded by the SLC5A2 (solute carrier family 5 (sodium/glucose cotransporter)) gene. [5] SGLT2 is a member of the sodium glucose cotransporter family, which are sodium-dependent glucose transport proteins.

Sodium-dependent glucose cotransporters (or sodium-glucose linked transporter, SGLT) are a family of glucose transporter found in the intestinal mucosa (enterocytes) of the small intestine (SGLT1) and the proximal tubule of the nephron (SGLT2 in PCT and SGLT1 in PST). They contribute to renal glucose reabsorption.

2023年6月3日 · Sodium-glucose cotransporter 2 (SGLT-2) inhibitors act on the SGLT proteins expressed in the proximal renal convoluted tubules. Four agents (canagliflozin, dapagliflozin, empagliflozin, ertugliflozin) are FDA-approved for managing adult patients with type 2 diabetes mellitus (DM) to improve blood sugar control adjunct to diet and exercise.

2021年12月8日 · Subsequently, coupled Na + /glucose transport was found to be mediated by sodium–glucose cotransporters 2, 3 (SGLTs). SGLTs are responsible for active glucose and galactose absorption in the...

Glucose transport across the cell membrane is mediated by two types of transporters: facilitative glucose transporters (gene name: solute carrier 2A) and sodium–glucose cotransporters (SGLTs; gene name: solute carrier 5A). Each transporter has its own substrate specificity, distribution, and regulatory mechanisms.

2023年12月6日 · Sodium–glucose cotransporter 2 (SGLT2) is imporant in glucose reabsorption. SGLT2 inhibitors suppress renal glucose reabsorption, therefore reducing blood glucose levels in...

Sodium-glucose cotransporter-2 (SGLT2) is selectively expressed in the human kidney, where it executes reabsorption of filtered glucose with a high capacity; it may be overactive in patients with diabetes, especially in the early, hyperfiltering stage of the disease.

4 天之前 · Wilcox, C. S. Antihypertensive and renal mechanisms of SGLT2 (sodium-glucose linked transporter 2) inhibitors. ... SGLT-2 inhibitors in heart failure: A review of current evidence - PMC. Accessed ...

SGLT2 inhibitors are an insulin-independent class of oral antihyperglycemic medication that clinicians use in the treatment of type 2 diabetes. Multiple landmark clinical trials support the effectiveness of SGLT2 inhibitors in reducing blood glucose levels, but it is important to understand when to properly utilize them.

2025年3月6日 · The 2024 American Diabetes Association Standards for the Management of Diabetes Mellitus recommends the use of a sodium-glucose co-transporter (SGLT) 2 inhibitor in patients with type 2 DM and CKD (defined as an estimated glomerular filtration rate of 20–60 mL/min/1.73 m 2 and/or albuminuria), to minimize the deterioration of DN and reduce ...