Nature封面：成人大脑中发现新生神经元！老年痴呆或许会有救！
2019年4月3日 · 形态学的分析结果表明，DCX+CR+主要位于颗粒细胞层（GCL）的肝门部边缘，称为亚颗粒区（SGZ），它们的体形较小，具有不成熟的细长形态特征，每个细胞有2个初 …
DCX + neuronal progenitors contribute to new oligodendrocytes …
2020年11月18日 · NPCs reside in the subgranular zone (SGZ) of the dentate gyrus (DG), one of two prominent regions of neurogenesis in the adult brain. During hippocampal neurogenesis, …
Subgranular zone - Wikipedia
The subgranular zone (SGZ) is a layer of cells in the dentate gyrus, in the hippocampal formation, which is a site of adult neurogenesis in the brain. [ 1 ] The other major site of adult …
Anti-RGMa neutralizing antibody ameliorates vascular cognitive ...
2025年3月2日 · Immunohistochemical analyses revealed that RGMa was primarily expressed in mature neurons in the GCL, whereas neogenin was primarily expressed in DCX-positive …
Frontiers | Distinct Features of Doublecortin as a Marker of …
2017年6月27日 · Studies have shown the expression of DCX in various regions of the developing nervous system. It is highly expressed in newly produced cells in the neurogenic zones; the …
J Neurosci︱浙江大学王朗课题组揭示成体海马新生神经元发育及 …
成体神经发生 是指哺乳动物中枢神经系统在成年后仍然能够持续产生新生神经元的现象，主要存在于 侧脑室下区 （svz）和 海马齿状回颗粒层下区 （sgz）。在成年大脑海马齿状回中产生的新 …
成年哺乳动物脑内海马齿状回颗粒下区（sgz）终生存在有神经干细胞，在某些生理或 病理因素刺激下，可增殖、分化为神经元和神经胶质细胞，迁移到损伤的脑区替换受损细胞，
Neurogenic effects of rotarod walking exercise in ... - Nature
2022年6月22日 · Several lines of evidence have described the pro-neurogenic role of BDNF in the SGZ and SVZ; however, there is a region-specific difference in its cognate receptor system, …
p21Cip1 restricts neuronal proliferation in the subgranular zone …
2008年1月1日 · Given the capacity of p21 to restrain the cell cycle, its localization in the SGZ, and its confinement to DCX-positive cells, p21 might play an important and unique role in …
Quiescent and Active Hippocampal Neural Stem Cells with Distinct ...
2010年5月7日 · In the subgranular zone (SGZ) of the adult hippocampal dentate gyrus (DG), NSCs (also referred to as Type-1 cells) produce intermediate progenitor cells (IPs, Type-2a …