快速了解Wnt/Hedgehog/Notch 通路 - 知乎 - 知乎专栏
2024年3月11日 · Notch 通路是一种经典的细胞-细胞接触依赖型信号传递机制，对于细胞分化、增殖以及决定细胞命运极为重要。 该通路通过接受细胞表面的Notch受体与发送细胞表面 …
快速了解Wnt/Hedgehog/Notch 通路 - TargetMol
Notch 通路是一种经典的细胞-细胞接触依赖型信号传递机制，对于细胞分化、增殖以及决定细胞命运极为重要。 该通路通过接受细胞表面的Notch受体与发送细胞表面的Jagged或Delta样配体 …
The crosstalk between the Notch, Wnt, and SHH signaling …
Here, we used a Notch antagonist (DAPT), a Wnt agonist (QS11), and recombinant Sonic hedgehog (SHH) protein to investigate their concerted actions underlying HC regeneration in …
SHH and Notch regulate SOX9+ progenitors to govern arcuate …
2022年8月11日 · Through pharmacological studies ex vivo, we demonstrate that while inhibiting either sonic hedgehog (SHH) or Notch signalling reduces the number of SOX9+ neural …
NOTCH, ERK, and SHH signaling respectively control the fate
We further demonstrate that, from Tri-IPCs, NOTCH signaling is crucial for the fate determination of astrocytes, while ERK signaling plays a prominent role in oligodendrocyte fate specification, …
Notch Activity Modulates the Responsiveness of Neural …
2015年5月5日 · Notch activity regulates subcellular localization of the Shh receptor Patched1, gating the translocation of the key effector Smoothened to primary cilia and its downstream …
Notch 信号通路的作用机制及检测方式是什么？ - 知乎
Notch 通路由四部分组成：Notch 受体 (Notch1/2/3/4)，Notch 配体 (Delta-like ligands, DLL1/3/4；Jagged ligands, JAG1/2)，CSL-DNA 结合蛋白，下游靶基因 (Hes 家族，MYC 等) …
Notch signaling is significantly suppressed in basal cell carcinomas ...
Several specific molecular mechanisms involved in this process of self-renewal, including the sonic hedgehog (Shh), Notch and Wingless-related integration site (Wnt) signaling pathways, …
SHH, WNT, and NOTCH pathways in medulloblastoma: when …
Methods: We quantified, by qPCR in 40 MB tumor samples, the expression of genes in HH (PTCH1, PTCH2, and GLI1), WNT (APC, CTNNB1, WIF1, and DKK2), and NOTCH pathways …
Unravelling the crosstalk of Hedgehog with Wnt, Notch and TGF-β ...
2024年1月1日 · RNA sequencing identified differentially expressed genes across all groups, revealing that supporting cell proliferation involves the SHh and Wnt signaling pathways. …
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