Sonic hedgehog protein (SHH) is a major signaling molecule of embryonic development in humans and other animals, encoded by the SHH gene. [5] This signaling molecule is key in regulating embryonic morphogenesis in all animals.

音猬因子 （Sonic hedgehog， SHH ）是5种刺猬（Hedgehog， HH ）因子（其他四种是沙漠刺猬因子， DHH 、印度刺猬因子， IHH 、Echidna Hedgehog， EHH 和Tiggywinkle Hedgehog， TwHH ）中的一种。 刺猬因子 是重要的信号传导途径。比如它决定 四肢 以及脑脊髓正中线的形成 …

2024年12月25日 · SHH (Sonic Hedgehog Signaling Molecule) is a Protein Coding gene. Diseases associated with SHH include Holoprosencephaly 3 and Solitary Median Maxillary Central Incisor. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Gastrulation.

The SHH gene encodes sonic hedgehog, a secreted protein that is involved in establishing cell fates at several points during development. SHH belongs to a family of vertebrate genes related to the Drosophila gene 'hedgehog' (hh) that encodes inductive signals during embryogenesis (Echelard et al., 1993; Roelink et al., 1994).

The SHH gene provides instructions for making a protein called Sonic Hedgehog. This protein functions as a chemical signal that is essential for embryonic development. Sonic Hedgehog plays a role in cell growth, cell specialization, and the normal shaping (patterning) of the body.

2025年2月8日 · It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar.

Sonic Hedgehog (Shh) signalling cascade is one of the intricate signal transduction mechanisms that govern the precisely regulated developmental processes of multicellular organisms. Along with establishing the patterns of cellular differentiation to direct complex organ formation, it also has an important role in post-embryonic tissue ...

Sonic Hedgehog induces Notch target gene expression in vascular smooth muscle cells via VEGF-A; sonic hedgehog (SHH)-dependent sequential activation of the transcription factors OLIG2, NKX2.2 and SOX10 is required for sequential specification of ventral spinal OLIG2-expressing progenitors

Of the three intracellular signaling proteins of the hedgehog family found in mammals, Sonic hedgehog (Shh) is the best known variant. It is involved in development of CNS, lungs, and intestine during embryogenesis and controls differentiation and self-renewal in adult stem cells.

Acting as cellular antenna, primary cilia transduce and regulate several signaling pathways such as Sonic hedgehog (SHH) and Wingless-activated (WNT) [1]. Among the various pathways, SHH is one of the most significant. SHH signaling remains quiescent in adult mammalian tissues.