WNT-modulating gene silencers as a gene therapy for …
SHN3 is a large, intracellular adaptor protein (>2,000 amino acids) that controls stabilization of β-catenin downstream of WNT signaling (Figure S1). 13 SHN3 acts as a potent inhibitor of bone …
Bone-targeting AAV-mediated silencing of Schnurri-3 prevents ... - Nature
2019年7月4日 · The adaptor protein Schnurri-3 (SHN3) is a promising therapeutic target for osteoporosis, as deletion of shn3 prevents bone loss in osteoporotic mice and short-term …
Engineering a targeted and safe bone anabolic gene therapy to …
2024年9月4日 · These results suggest that HFV-induced dual silencing of Shn3 and Sost is more effective than single silencing of Shn3 in enhancing WNT signaling and osteoblast activity and …
Bone-targeting AAV-mediated silencing of Schnurri-3 prevents ... - PubMed
2019年7月4日 · The adaptor protein Schnurri-3 (SHN3) is a promising therapeutic target for osteoporosis, as deletion of shn3 prevents bone loss in osteoporotic mice and short-term …
许韧团队连续发文多维度解析新型促成骨化靶点-“Schnurri-3”的临 …
2024年8月26日 · 该研究阐明了通过调控骨shn3-slit2轴，不仅可能治疗骨质疏松症，而且有助于改善肥胖相关代谢性疾病。 该研究同时针对这两种严重危害人类健康的慢性疾病，对未来开发 …
WNT-modulating gene silencers as a gene therapy for
2023年2月1日 · Taken together, systemic delivery of bone-targeted rAAV carrying gene silencers targeting Shn3, Sost, or both could be a promising therapeutic approach for both …
骨靶向 AAV 介导的 Schnurri-3 沉默可防止骨质疏松 ... - X-MOL
衔接蛋白 Schnurri-3 (SHN3) 是一个很有前途的骨质疏松症治疗靶点，因为删除 shn3 可以防止骨质疏松小鼠的骨质流失，而短期抑制 shn3 可以增加成年小鼠的骨量。
sclerostin (SOST) and schnurri-3 (SHN3, also Hivep3), have been considered promising targets to promote bone formation in osteo-porosis and fracture healing. SOST is a secreted antagonist …
An angiogenic approach to osteoanabolic therapy targeting the SHN3 …
2023年7月1日 · SLIT3 is a SHN3-regulated skeletal angiogenic factor produced by osteoblasts. Increasing skeletal angiogenesis via the SHN3/SLIT3 pathway is an attractive osteoanabolic …
WNT 调节基因沉默剂作为骨质疏松症、骨折和临界骨缺损的基因 …
使用携带人工 microRNA (miRNA) 的骨靶向 rAAV 治疗可沉默 WNT 拮抗剂、schnurri-3 (SHN3) 和硬化素 (SOST) 的表达，并增强 WNT/β-连环蛋白信号传导、成骨细胞功能和骨形成。