2017年12月6日 · Haploinsufficiency of short stature homeobox containing gene (SHOX) is one of the prevalent monogenic causes of short stature. SHOX is located in the pseudoautosomal …

2005年12月12日 · The phenotypic spectrum of SHOX deficiency disorders, caused by haploinsufficiency of the short stature homeobox-containing gene (SHOX), ranges from …

Using U2OS osteosarcoma cells with inducible SHOX expression, Hristov et al. (2014) found that SHOX elevated cellular content of reactive oxygen and nitrogen species, induced lysosomal …

2000年8月1日 · The multitude of growth-affecting genetic factors has recently been supplemented by the discovery of the homeobox gene SHOX. Although originally described as causing …

2016年6月29日 · SHOX deficiency is the most frequent genetic growth disorder associated with isolated and syndromic forms of short stature. Caused by mutations in the homeobox gene …

Pathway and network analyses have identified interactors, target genes, and regulators. Here, we summarize recent data and give insight into the critical molecular and cellular functions of …

2016年6月29日 · SHOX deficiency is the most frequent genetic growth disorder associated with isolated and syndromic forms of short stature. Caused by mutations in the homeobox gene …

2013年11月1日 · We found that SHOX expression induces the intrinsic mitochondrial pathway of apoptosis leading to caspase activation. SHOX-induced apoptosis is associated with …

2014年3月15日 · We show that SHOX expression in U2OS osteosarcoma cells leads to oxidative stress that, in turn, induces lysosomal membrane rupture with release of active cathepsin B to …

Here we demonstrate that SHOX expression in osteogenic stable cell lines, primary oral fibroblasts, and primary chondrocytes leads to cell cycle arrest and apoptosis. These events …