Amber Shun-Shion currently works at the Department of Biomedical Science, The University of Sheffield. Amber does research in Molecular Biology and Cell Biology. Her current project is...

2021年10月4日 · Amber Shun-Shion Phosphoproteomics reveals rewiring of the insulin signaling network and multi-nodal defects in insulin resistance 2022-05-27 | Preprint

Insulin promotes glucose uptake into these tissues by triggering a protein phosphorylation signalling cascade, which converges on multiple trafficking processes to deliver the glucose transporter GLUT4 to the cell surface.

Cell culture is often considered to be hyperoxic, but pericellular oxygen levels, which are affected by oxygen diffusivity and consumption, are rarely reported. Here, we provide evidence that several cell types in culture actually experience local hypoxia, with important implications for cell metabolism and function.

Amber S. Shun-Shion's 8 research works with 29 citations and 1,519 reads, including: Insulin signalling and GLUT4 trafficking in insulin resistance

2023年2月18日 · Protein phosphorylation is central to the adipocyte insulin response, but how adipocyte signaling networks are dysregulated upon insulin resistance is unknown. Here we employ phosphoproteomics to delineate insulin signal transduction in …

We have developed a panel of quantitative flow cytometry-based assays and reporter cell lines that can be used to measure constitutive secretion. These assays are insensitive to changes in cell number making them very robust and well suited to functional genomic and chemical screens.

2020年11月22日 · We have developed a panel of quantitative flow cytometry-based assays and reporter cell lines that can be used to measure constitutive secretion. These assays are insensitive to changes in cell number making them very robust and well suited to functional genomic and chemical screens.

2018年10月22日 · STX19 是一种不寻常的 Qa-SNARE，因为它缺乏 C 端跨膜结构域。 然而，它有效地靶向后高尔基膜。 在这里，我们着手确定内源性 STX19 的细胞内定位，并阐明它靶向膜的机制。 我们发现 STX19 池定位于管状循环内体，与 MICAL-L1 和 Rab8（具有 Rab8a 和 Rab8b 形式）共定位。 使用遗传、生化和基于细胞的方法的组合，我们已经确定 STX19 在其 C 端是 S- 酰化的，并且是几种高尔基体 S- 酰基转移酶的底物，这表明 STX19 最初在贩运到质膜和内体 …

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