2016年10月13日 · BAP1 tumor predisposition syndrome (BAP1-TPDS) is associated with increased risk for a specific skin lesion, BAP1-inactivated melanocytic tumor (BIMT; formerly called atypical Spitz tumor), and several cancers including uveal (eye) melanoma (UM), malignant mesothelioma (MMe), renal cell carcinoma (RCC), cutaneous melanoma (CM), basal cell ...

2023年8月22日 · Germline BAP1 pathogenic/likely pathogenic variants are associated with predisposition to multiple tumours, including uveal melanoma, malignant pleural and peritoneal mesothelioma, renal...

在本研究中，我们首先证明bap1可以显着保护葡萄糖饥饿引起的二硫键下垂，并通过各种细胞死亡抑制剂和细胞骨架蛋白中二硫键的积累得到验证。 已知 BAP1 会抑制 SLC7A11 的表达。

In this review, we summarize the current state of knowledge regarding the biological functions of BAP1, potential use of BAP1 signature in therapeutics, and advances in the field of targeted therapy of BAP1 mutated tumors.

BRCA1-associated protein 1 (BAP1) is emerging as an intensively studied cancer-associated gene. Germline mutations in BAP1 lead to a cancer syndrome, and somatic loss is found in several cancer types. BAP1 encodes a deubiquitinase enzyme, which plays key roles in cell cycle regulation, cell death, and differentiation.

2024年12月24日 · BAP1 (BRCA1 Associated Deubiquitinase 1) is a Protein Coding gene. Diseases associated with BAP1 include Kury-Isidor Syndrome and Tumor Predisposition Syndrome 1. Among its related pathways are Metabolism of proteins and HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA).

BAP1 modulates crucial cellular pathways that regulate genomic stability and cell death. BAP1 mutations on the one hand favor malignant transformation and mesothelioma development; on the other hand, they reduce mesothelioma aggressiveness.

2023年2月8日 · Here, we show that BAP1 is upregulated in colon cancer cells and tissues and that BAP1 depletion reduces colon cancer cell proliferation and tumor growth. BAP1 contributes to colon cancer...

BAP1 IHC is a prognostic test in uveal melanoma. Classification is as follows: if < 33% of tumor nuclei are positive, classify as low. If ≥ 33% are positive, classify as high. The tumor proportion score is estimated by manual quantification or digital image analysis. The photomicrograph shows BAP1 in uveal melanoma.

2022年9月30日 · We report the identification of the methyl-CpG-binding domain proteins 5 and 6 (MBD5 and MBD6) that bind to the C-terminal PHD fingers of the large scaffold subunits ASXL1-3 and stabilize the BAP1 complex at the chromatin.