2024年3月26日 · Post microinjection with Nr5a2 interference fragment (Si) or negative control (NC), zygotes were cultured to the 2-cell stage, then transplanted into the fallopian tubes of E0.5 pseudopregnant CD-1 surrogate mothers.

2022年12月7日 · 为了揭开哺乳动物中合子基因组激活的关键调控因子，德国马克斯普朗克生化研究所Kikuë Tachibana研究组在Science发表了题为Zygotic genome activation by the totipotency pioneer factor Nr5a2的研究论文，发现 孤儿核受体Nr5a2 会作为先锋因子（Pioneer factor）激活小鼠胚胎全基因组的 ...

2016年7月22日 · Overexpression and loss-of-function experiments in primary NSCs and mouse embryos suggest that NR5A2 synchronizes cell-cycle exit with induction of neurogenesis and inhibition of astrogliogenesis...

2023年5月18日 · In the present study, we provided in vitro and in vivo evidence that heat shock protein gp96 promoted AFP expression at the transcriptional level in HCC. NR5A2 was identified as a key transcription factor for the AFP gene, and its stability was enhanced by gp96.

Zhao et al. demonstrate that Nr5a2 is significant in early mouse embryos, revealing its targeting of ICM-specific genes, including Oct4, to form the pluripotency network and ensure ICM formation in the blastocyst. Recent studies have elucidated Nr5a2’s role in activating zygotic genes during early mouse embryonic devel-opment.

Our data show that nuclear receptor NR5A2 suppresses the growth of glioblastomas and neuroblastomas. This function is facilitated by the ability of NR5A2 to induce critical cell cycle inhibitors including p21, p27, and Prox1.

Using the LLC‐SD model, through transient and stable siRNA interference of Nr5a2 expression, we provided convincing evidence for a regulatory role of Nr5a2 in the maintenance of lung CSC self‐renewal and stem cell properties in vitro.

由该基因编码的蛋白质是一种结合 DNA 的锌指转录因子，是孤儿核受体 fushi tarazu 因子-1 亚家族的成员。 编码的蛋白质参与乙型肝炎病毒和胆固醇生物合成基因的表达，可能是胚胎发育的重要调节因子。 [RefSeq 提供，2016 年 6 月] The protein encoded by this gene is a DNA-binding zinc finger transcription factor and is a member of the fushi tarazu factor-1 …

2024年2月26日 · Nr5a2 is a key pioneer factor that regulates zygotic genome activation in totipotent embryos, pluripotency in embryonic stem cells and metabolism in adult tissues, but the mechanism of its...

2024年3月26日 · Post microinjection with Nr5a2 interference fragment (Si) or negative control (NC), zygotes were cultured to the 2-cell stage, then transplanted into the fallopian tubes of E0.5 pseudopregnant CD-1 surrogate mothers.