Many of the lentiviral transfer vectors that have been deposited with Addgene are self-inactivating (SIN) vectors. These vectors have a deletion in the 3'LTR of the viral genome that is …

The HIV-1-based SIN vector presented here offers all of the previously claimed advantages of SIN retroviral vectors. First, the extensive U3 deletion of SIN-18 abolishes the viral promoter …

从实验的角度来看，慢病毒和标准逆转录病毒（γ-逆转录病毒）之间的主要区别在于，慢病毒能够感染非分裂和主动分裂的细胞类型，而标准逆转录病毒只能感染有丝分裂活跃的细胞类型。 …

慢病毒载体 （Lentiviral vectors, LVs）是在人免疫缺陷病毒（HIV-1病毒）基础上改造而成的病毒载体系统，它能高效的将 目的基因 （或 RNAi）导入动物和人的原代细胞或细胞系，对分裂细 …

We have developed a scalable LVV platform for rapid and consistent vector production with minimal process development. With decades of experiences and reproducible process data, …

2024年6月13日 · 进一步， 经过健新原力工艺团队的开发，使用MOI=0.5的BaEV-LVV，可实现更高转染效率(80.1%)（图2），这不仅降 低CAR-NK细胞中插入的CD19基因拷贝数（EMA规 …

2018年3月22日 · The introduction of deletions into the 3'LTR of the viral genome to create self-inactivating (SIN) lentiviral vectors disrupted the promoter/enhancer activity of the LTR, further …

2009年10月22日 · Lentiviral vectors (LVs) offer the advantages of a large packaging capacity, broad cell tropism or specific cell-type targeting through pseudotyping, and long-term …

Lentiviral vectors (LVV) are efficient gene transfer vehicles used in a growing list of gene therapy applications that are currently being evaluated clinically. We are conducting clinical trials in …

A self-inactivating (SIN) vector was constructed by deleting 133 bp in the U3 region of the 3' LTR, including the TATA box and binding sites for transcription factors Sp1 and NF-kappaB. The …