Small interfering RNA (siRNA), sometimes known as short interfering RNA or silencing RNA, is a class of double-stranded non-coding RNA molecules, typically 20–24 base pairs in length, similar to microRNA (miRNA), and operating within the RNA interference (RNAi) pathway.

2021年5月13日 · siRNA is a double-stranded RNA molecule that is non-coding. It is also known as silencing RNA and short interfering RNA. It is similar to microRNA (miRNA) and the structure is short and...

One of the most important advances in biology has been the discovery that siRNA (small interfering RNA) is able to regulate the expression of genes, by a phenomenon known as RNAi (RNA interference). The discovery of RNAi, first in plants and ...

2019年9月4日 · The siRNA is also known as small interfering ribonucleic acid or silencing RNA and is a molecule that prevents gene expression. This means it silence genes. The entire process of gene silencing through the siRNA is called a mechanism of RNA interference or …

2021年8月15日 · Owing to specific and compelling gene silencing, RNA interference (RNAi) is expected to become an essential approach in treating a variety of infectious, hemato-oncological, cardiovascular, and neurodegenerative conditions.

In this review, we discuss prospective targets for siRNA drug design, explain siRNA drug properties and benefits, and give an overview of the current clinical siRNA therapeutics for the treatment of cancer.

2020年6月19日 · All clinically explored and commercialized siRNA delivery platforms, including the GalNAc (N-acetylgalactosamine)–siRNA conjugate, and their fundamental design principles are thoroughly...

2024年5月30日 · The siRNA is a molecule that inhibits gene expression. It is also known as tiny interfering ribonucleic acid or silencing RNA. This implies that it silences genes. The overall process of siRNA-mediated gene silencing is known as RNA interference or siRNA knockdown.

Two primary categories of these small RNAs— short interfering RNAs (siRNAs) and microRNAs (miRNAs)—act in both somatic and germline line-ages in a broad range of eukaryotic species to regulate endogenous genes and to defend the genome from invasive nucleic acids.

Small interfering RNA (siRNA), also known as short interfering RNA or silencing RNA, is a class of double-stranded RNA molecules (20–25 bp length) and interferes with the expression of specific genes with complementary nucleotide sequences. RNAi has been a promising therapeutic approach for diseases with aberrant protein production.