Signal regulatory protein g (SIRPγ) is uniquely expressed by human T-cells, compared to other immunomodulatory SIRP family members. The role of SIRPγ in T cell function is largely uncharacterized despite accumulating evidence in the literature linking SIRPγ to autoimmune diseases including T1D and SLE.

Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells [citation needed] or neurons. SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don't eat me" signal.

2022年3月1日 · Here we showed that signal regulatory protein γ (SIRPγ) determined CSLC properties and immune evasiveness in a small population of lung adenocarcinoma (LUAD) cancer cells. A SIRPγhi population displayed CSLC properties and transmitted the immune escape signal through sustaining CD47 expression in both SIRPγhi and SIRPγlo/- tumor cells.

2006年5月12日 · Members of the signal-regulatory protein (SIRP) family, which are expressed mainly by myeloid cells, provide one example of these regulatory membrane proteins. There are three SIRP-family genes...

信号调节蛋白γ： 该基因编码的蛋白质是信号调节蛋白 (sirp) 家族的一员，也属于免疫球蛋白超家族。 sirp 家族成员是受体型跨膜糖蛋白，已知参与受体酪氨酸激酶偶联信号传导过程的负调节。已经描述了编码不同亚型的选择性剪接转录物变体。

The signal regulatory protein (SIRP) family consists of an inhibitory receptor, SIRPα, an activating receptor, SIRPβ [also known as cluster of differentiation (CD)172b] and a non-signaling receptor, SIRPγ (also known as CD172g) (1,2).

Soluble signal regulatory protein-alpha (SIRP-alpha) is elevated in bronchoalveolar lavage (BAL) of mice with lipopolysaccharides (LPS)-induced acute lung injury (ALI). To define the role of soluble SIRP-alpha in the pathogenesis of ALI, we ...

SIRPα (Signal regulatory proteinα)是SIRP家族中的一个典型的抑制性免疫受体，其可以选择性地表达于髓系细胞和神经细胞膜表面； CD47 是一种各种细胞广泛表达的类Ig膜蛋白，可与多种细胞表面受体相互作用。

The present study investigated the regulatory mechanism of signal-regulatory protein (SIRP)-α in the apoptosis and proliferation of prostate cancer (CaP) cells. The expression profile of SIRP-α in prostate cancer cells was analyzed using reverse transcription-quantitative polymerase chain …

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