NAD-dependent deacetylase sirtuin 7 is an enzyme that in humans is encoded by the SIRT7 gene. [5][6][7] SIRT7 is member of the mammalian sirtuin family of proteins, which are …

2024年12月25日 · SIRT7 (Sirtuin 7) is a Protein Coding gene. Diseases associated with SIRT7 include Lysosomal Storage Disease and Prostate Cancer. Among its related pathways are …

As a member of the Sirtuins family in mammals, SIRT7 locates in nucleus and is a highly specific H3K18Ac (acetylated lysine 18 of histone H3) deacetylase. Recent studies showed that SIRT7 …

2024年2月21日 · SIRT7 distinguishes itself as the exclusive mammalian Sirtuin primarily localized within the nucleolus, a crucial organelle involved in ribosome biogenesis. In this compartment, …

2025年2月4日 · Here, we report structures of nucleosome-bound SIRT7, and uncover the structural basis of its specificity towards H3K36 and K18 deacylation, combining a mechanism …

2023年9月19日 · SIRT7通过去乙酰化Fibrillarin和PAF53促进RNA polymerase I介导的rRNA的转录。SIRT7还可以直接去乙酰化U3-55k进而调控U3 snoRNA对18S rRNA的成熟加工过程。

2016年7月20日 · We show that SIRT7 is recruited to DNA double-strand breaks (DSBs) in a PARP1-dependent manner and catalyses desuccinylation of H3K122 therein, thereby …

SIRT7, a member of the sirtuin family of NAD +-dependent protein deacetylases, is a key mediator of many cellular activities. SIRT7 expression is linked to cell proliferation and …

sirt7能够支持心脏细胞功能，保护心肌细胞免受氧化应激和炎症损伤，延缓心脏因年龄增长而出现的退化。此外，sirt7还与dna修复相关，可以延长心脏细胞的寿命，帮助维持心血管系统的稳 …

2017年1月1日 · Mammalian SIRT7 is a member of the sirtuin family that regulate multiple biological processes including genome stability, metabolic pathways, stress responses, and …