2024年7月2日 · Heterologous (alternating PICV/LCMV) immunization with artArena or rArena vectors stimulated significantly stronger T-cell responses when compared with homologous administration (PICV/PICV or LCMV/LCMV), as evident from comparison of magnitude of IFN-γ ELISpot responses against both encoded SIV antigens (Env and Gag; Figure 2 and Supplementary ...

2023年11月10日 · Here, we studied the application of two attenuated, replicating arenavirus vectors—artPICV (based on Pichindé virus strain p18, with artificial genomic arrangement) and artLCMV (based on...

2024年6月3日 · Arenaviral vaccine vectors encoding simian immunodeficiency virus (SIV) immunogens are capable of inducing efficacious humoral and cellular immune responses in nonhuman primates. Several studies have evaluated the use of immune modulators to further enhance vaccine-induced T-cell responses.

Our study shows that immunization of naïve rhesus macaques with arenavirus-derived vaccine vectors encoding simian immunodeficiency virus (SIVSME543 Gag, Env, and Pol) immunogens is safe,...

2015年2月27日 · Control of acute infections with LCMV and PICV is mediated by virus-specific CD8 T cells, and increased numbers of LCMV- and PICV-specific IFN-γ-expressing CD8 T cells were in the spleens of NK...

The analyses published were conducted with a simian immunodeficiency virus (SIV) model, commonly used in a preclinical setting as a surrogate to HIV. The data show that: Arenaviral therapeutic vaccination was well tolerated and generated robust, high-quality and durable immune responses (antigen-specific T cells and antibodies) in non-human ...

2024年6月3日 · 文章内容提到的"PICV"是"Pressure-Independent Control Valve"的缩写，直译为“压力独立控制阀”。 这个术语在学术和建筑领域中被广泛使用，特别是在描述一种能够独立于系统压力

2023年5月15日 · In the present paper, we compare the performance of traditional manual balancing valves and new pressure independent control valves (PICVs), used to balance the hydronic loop of HVAC systems.

Article Title: Arenavirus-Based Vectors Generate Robust SIV Immunity in Non-Human Primates. doi: 10.3390/vaccines12070735. Figure Lengend Snippet: Comparison between heterologous immunization of artPICV/artLCMV and rPICV/rLCMV vector for generating SIV envelope binding IgG titers and anti-vector (LCMV and PICV) neutralization antibody titers ...

This CPD will consider the application of pressure-independent control valves (PICV) to provide stable operating conditions – and so consistent control – at each terminal load. Many heating and cooling loads in commercial and industrial buildings can be controlled by varying the water flowrate – notably heating and cooling coils in air ...