lyve-1表达于初始淋巴管独特的松散连接处，在白细胞进入时打开的叉指状内皮瓣尖端，其位置指示重要的生理功能。lyve-1通过与dc表面排列的ha结合来介导迁移（图1）。lyve-1更倾向于与大型多价ha蛋白复合物的相互作用，而不是游离ha链。 图1.

2002年11月22日 · We have isolated primary lymphatic and blood microvascular endothelial cells from human skin by immunoselection with the lymphatic marker LYVE-1 and demonstrate that the two cell lineages express distinct sets of vascular markers and respond differently to growth factors and extracellular matrix.

2025年3月20日 · Instrumental to the migration of antigen-scavenging immune cells, the lymphatic vessel entry receptor LYVE-1 interacts with the hyaluronan glycocalyx, anchored by the leucocyte hyaluronan...

2017年5月15日 · Using Lyve1−/− mice and function-blocking monoclonal antibodies (mAbs), we found that efficient lymphatic trafficking of DCs from inflamed skin was dependent on LYVE-1, and that LYVE-1–HA...

2021年10月18日 · Antibody-mediated blockade of LYVE-1, CD99 and JAM-A in ear explant assays resulted in a marked decrease in CD11c + DC immigration into skin lymphatics at ZT7 (day) compared to isotype-treated...

2018年8月21日 · LYVE-1 + macrophages were also found on human SMA + vasculature in the dermis of abdominal skin (Figures 4 H and S3 E) and in umbilical cord (Figure 4 I). These data reveal the exclusive distribution of LYVE-1 + macrophages in the adventitia of SMA + large blood vessels and provide preliminary evidence that this subset of perivascular ...

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1999年2月22日 · However, unlike CD44, the LYVE-1 molecule colocalizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE-1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves.

LYVE-1 (Lymphatic Vessel Endothelial Receptor 1) is a CD44 homolog found primarily on lymphatic endothelial cells. 1 While LYVE-1 functions continue to be defined, potential roles have been suggested in hyaluronan (HA) transport and turnover, or in promoting HA localization to the surfaces of lymphatic endothelium.

2016年5月13日 · Lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1), a type I transmembrane glycoprotein, is known as one of the most specific lymphatic vessel markers in the skin. In this study, we found that the ectodomain of LYVE-1 undergoes proteolytic cleavage, and this process produces soluble LYVE-1. …