Stem cell competition orchestrates skin homeostasis and ageing
2019年4月3日 · Stem cells with higher potential or quality are thus selected for homeostasis, but their eventual loss of COL17A1 limits their competition, thereby causing ageing. The resultant …
Stem Cell-Derived Exosomes: A New Method for Reversing Skin Aging
2022年7月9日 · Determining a means to delay or even reverse skin aging has become a research hotspot in medical cosmetology and anti-aging. Dysfunction in the epidermis and fibroblasts …
Human skin aging is associated with increased expression of
2021年4月1日 · Here, we investigate histone variant H2A.J as a new biomarker to detect senescent cells during human skin aging. Skin biopsies from healthy volunteers of different …
A stem cell aging framework, from mechanisms to interventions
2022年10月18日 · In this review, we elucidate aging-related features across different somatic stem cell types, with a specific focus on epigenetic changes, loss of protein homeostasis, and …
Ageing and rejuvenation of tissue stem cells and their niches
2022年7月20日 · Stem cell function is critical for tissue homeostasis and repair upon injury, and it is dependent on interactions with the niche. During ageing, stem cells decline in their …
Stem cells to reverse aging - PMC - PubMed Central (PMC)
Stem cell (SC) therapies have broad application prospects in the field of regenerative medicine due to the inherent biological characteristics of SCs, such as their plasticity, self-renewal, and …
Stem cell aging: mechanisms, regulators and therapeutic …
Here we explore key molecular pathways that are commonly perturbed as tissues and stem cells age and degenerate. We further consider experimental evidence both supporting and refuting …
Stem cells and healthy aging | Science - AAAS
2015年12月4日 · Research into stem cells and aging aims to understand how stem cells maintain tissue health, what mechanisms ultimately lead to decline in stem cell function with age, and …
Influences on Skin and Intrinsic Aging: Biological, Environmental, …
Stem cell therapy uses stem cell–derived products and treatments to leverage the regenerative potential of stem cells for repairing and rejuvenating aging skin . Platelet‐rich plasma (PRP) …
Human skin stem cells and the ageing process - PubMed
The self-renewal and multi-lineage differentiation of skin stem cells make these cells attractive for ageing process studies but also for regenerative medicine, tissue repair, gene therapy and cell …