The surface antigen CD319 (SLAMF7) is a robust marker of normal plasma cells and malignant plasma cells in multiple myeloma. In contrast to CD138 (the traditional plasma cell marker), CD319/SLAMF7 is much more stable and allows robust isolation of malignant plasma cells from delayed or even cryopreserved samples.

2024年12月25日 · SLAMF7 (SLAM Family Member 7) is a Protein Coding gene. Diseases associated with SLAMF7 include Plasmablastic Lymphoma and Smoldering Myeloma. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to …

信号淋巴细胞激活分子成员7（signaling lymphocytes activating molecule factor 7, SLAMF7）是一种相对分子量为66 kDa的跨膜蛋白受体，属免疫球蛋白超家族成员。 其分子结构包括胞外区、跨膜区和胞内区三个部分。 其中，胞内区带有富含酪氨酸的免疫受体转换基序（ITSMs；T-V/I-Y-x-x-V/I） [1] 内含两个保守酪氨酸Y281和Y261，分别参与SLAMF7的激活和抑制信号通路 [2]。 SLAMF7蛋白可分为两种主要亚型：SLAMF7-Long型和SLAMF7-Short型。 研究发现，免疫 …

2017年4月19日 · Using a mouse lacking the signalling lymphocytic activation molecule (SLAM) family of homotypic haematopoietic cell-specific receptors, we determined that phagocytosis of haematopoietic tumour...

2022年12月17日 · bitns将实体肿瘤细胞从低免疫原性转化为slamf7高表型，高效地促进了巨噬细胞吞噬肿瘤细胞和呈递肿瘤抗原，大大增强了cd47抑制剂和pd1抑制剂的疗效。

SLAMF7 binds EAT-2, but not SAP [169-171], and two isoforms of SLAMF7 have been identified: CS-1 long (CS1-L) and CS-1 short (CS1-S) . While CS1-S does not bind EAT-2, CS1-L binds EAT-2 and induces NK cell mediated cytotoxicity.

1 天前 · The SLAMF7 gene is located on the long arm of human chromosome 1 and contains seven exons. 16,17 The −750 to −746 region of its promoter contains a zinc finger transcriptional repressor Blimp-1 (PRDM1) binding site (GAAAG), which activates human SLAMF7 transcription when bound to Blimp-1. 18 SLAMF7 is also expressed in cells that do not express Blimp-1, suggesting that SLAMF7 is also ...

2021年1月1日 · In this study, we show that activation of the self-ligand SLAMF7 immune receptor on T cells induced STAT1 and STAT3 phosphorylation, expression of multiple inhibitory receptors, and transcription factors associated with T cell exhaustion.

2017年4月27日 · In contrast to most SLAM receptor functions, SLAMF7-mediated phagocytosis was independent of signalling lymphocyte activation molecule-associated protein (SAP) adaptors. Instead, it depended on the ability of SLAMF7 to interact with integrin Mac-1 (refs 18, 19, 20) and utilize signals involving immunoreceptor tyrosine-based activation motifs.

信号淋巴细胞激活分子成员7（signaling lymphocytes activating molecule factor 7, SLAMF7）是一种相对分子量为66 kDa的跨膜蛋白受体，属免疫球蛋白超家族成员。 其分子结构包括胞外区、跨膜区和胞内区三个部分。 其中，胞内区带有富含酪氨酸的免疫受体转换基序（ITSMs；T-V/I-Y-x-x-V/I） 1 内含两个保守酪氨酸Y281和Y261，分别参与SLAMF7的激活和抑制信号通路 2。 SLAMF7蛋白可分为两种主要亚型：SLAMF7-Long型和SLAMF7-Short型。 研究发现，免疫 …