By contrast, many cell types express SLC16A2 and THRA. Conclusions: SLCO1C1 and DIO2 coexpression in the outer radial glia, the universal stem cell of the cerebral cortex, highlights …

2015年5月5日 · Of these transporters, monocarboxylate transporter 8 (MCT8) is the only one specific for the transport of thyroid hormones and some of their derivatives. Mutations in …

A mutation in the MCT8 (SLC16A2) gene (located on the X chromosome) causes an X-linked psychomotor intellectual disability, due to limited thyroid hormone uptake at the blood brain …

四个（SLC16A1， SLC16A3， SLC16A7 和 SLC16A8）编码单羧酸盐转运蛋白（分别为MCT1，MCT4，MCT2和MCT3）催化质子联结的质子传递的单羧酸盐，例如 1- 乳酸，丙酮 …

The Slc16a2/Slco1c1 (MO) and Slc16a2/Dio2 (MD) double knockout (KO) mice lacking T4 and T3 transport, or T3 transport and T4 deiodination, respectively, should be appropriate models of …

2021年10月18日 · We find that DIO2 and SLCO1C1 coexpress in glia, notably the outer radial glia, THRB is present mainly in GABAergic interneurons, and SLC16A2 and THRA show …

SLC16A2 encodes a high affinity thyroid hormone transporter (MCT8) and SLC16A10 an aromatic amino acid transporter (TAT1). The substrates and roles of the remaining eight members are …

2008年12月1日 · The importance of transport for thyroid hormone signaling was highlighted by the discovery that inactivating mutations in the human monocarboxylate transporter-8 (MCT8) …

SLCO1C1) is the primary thyroid hormone transporter at the blood brain barrier, while MCT8 mediates thyroid hormone uptake into neurons. In contrast to these reports, we report here …

Allan-Herndon-Dudley syndrome is a rare disease caused by inactivating mutations in the SLC16A2 gene, which encodes the monocarboxylate transporter 8 (MCT8), a transmembrane …