The solute carrier family 18 member 2 (SLC18A2) also known as vesicular monoamine transporter 2 (VMAT2) is a protein that in humans is encoded by the SLC18A2 gene. [5] VMAT2 is an integral membrane protein that transports monoamines —particularly neurotransmitters such as dopamine , norepinephrine , serotonin , and histamine —from cellular ...

2024年12月25日 · Electrogenic antiporter that exchanges one cationic monoamine with two intravesicular protons across the membrane of secretory and synaptic vesicles. Uses the electrochemical proton gradient established by the V-type proton-pump ATPase to accumulate high concentrations of monoamines inside the vesicles prior to their release via exocytosis.

2023年11月1日 · Two vesicular monoamine transporters 9, 10, 11, VMAT1 (encoded by SLC18A1) and VMAT2 (encoded by SLC18A2), are responsible for the packaging of monoamine neurotransmitters, including serotonin...

The SLC18A2 gene is hypermethylated and downregulated in prostate cancer (PC). SLC18A2 hypermethylation has promising diagnostic biomarker potential for PC. Study found that 2 promoter regions of Vesicular monoamine transporter 2 (hVMAT2) are associated with Parkinson's disease.

该基因编码一种跨膜蛋白，作为依赖 ATP 的单胺转运蛋白发挥作用，例如多巴胺、去甲肾上腺素、血清素和组胺。 这种蛋白质将胺类神经递质转运到突触小泡中。 该基因的多态性可能与精神分裂症、双相情感障碍和其他神经/精神疾病有关。 [RefSeq 提供，2018 年 6 月] This gene encodes an transmembrane protein that functions as an ATP-dependent transporter of monoamines, such as dopamine, norepinephrine, serotonin, and histamine.

哺乳动物中主要存在两种单胺转运蛋白VMAT2和VMAT1（也分别称为 SLC18A2 和 SLC18A1），属于Major Facilitator Superfamily。 尽管两者序列相似性超过 60%，但这两种 VMAT 在细胞分布、底物识别和药理学特征方面存在显

We evaluated genotype-phenotype correlations and the missense variants in the affected individuals based on the structural modeling of rat VMAT2 encoded by Slc18a2, with cytoplasm- and lumen-facing conformations.

2025年1月4日 · Title: VMAT2 gene (SLC18A2) variants associated with a greater risk for developing opioid dependence. SV2 was highly expressed in neuroblastoma (NB) and can thus be useful marker in NB diagnostics. VMAT1 and VMAT2 were also expressed in NB but similar to syn less reliable as tumor markers.

大脑vmat2，由slc18a2基因(omim 193001)编码，促进多巴胺和 血清素 加载到突触囊泡，运输到细胞膜和随后释放。slc18a2双等位基因功能障碍导致脑单胺泡性转运病(婴儿起病帕金森-肌张力障碍2;618049)。

2025年2月8日 · Human ortholog (s) of this gene implicated in Parkinson's disease; infantile parkinsonism-dystonia 2; and type 1 diabetes mellitus. Orthologous to human SLC18A2 (solute carrier family 18 member A2). [provided by Alliance of Genome Resources, Feb 2025]