2024年12月25日 · SLC20A1 (Solute Carrier Family 20 Member 1) is a Protein Coding gene. Diseases associated with SLC20A1 include Leukemia and Cloacal Exstrophy. Among its related pathways are Transport of inorganic cations/anions and amino acids/oligopeptides and 2q13 copy number variation syndrome.

由该基因编码的蛋白质是钠-磷酸盐同向转运蛋白，可从间质液中吸收磷酸盐，用于细胞功能，如新陈代谢、信号转导以及核酸和脂质合成。 编码的蛋白质也是一种逆转录病毒受体，导致人类细胞易受长臂猿白血病病毒、猿猴肉瘤相关病毒、猫白血病病毒亚组 B 和 10A1 鼠白血病病毒的感染。 [RefSeq 提供，2011 年 3 月]

Sodium-dependent phosphate transporter 1 is a protein that in humans is encoded by the SLC20A1 gene. [5][6] Retrovirus receptors allow infection of human and murine cells by various retroviruses.

Identification of a novel transport-independent function of PiT1/SLC20A1 in the regulation of TNF-induced apoptosis. PiT1 depletion markedly reduces cell proliferation, delays cell cycle, and impairs mitosis and cytokinesis. An overexpression of Pit-1 seems to play a key role in the formation of soft tissue calcification in Werner syndrome.

2024年1月9日 · Here we show that Slc20a1 (PiT-1) and Slc20a2 (PiT-2) are the most abundant Na-Pi co-transporters expressed in the brain and are involved in the control of hippocampal-dependent learning and...

2025年1月10日 · SLC20A1基因检测的意义在于帮助我们理解与该基因相关的多种生理和病理过程，包括其在磷酸盐和硫酸盐转运中的关键作用，以及与某些遗传性疾病的可能关联。 什么是SLC20A1基因？ SLC20A1基因，也叫PiT-1或Glvr-1，它位于我们染色体的2号上，具体在q14.1的位置。这个基因属于“Solute carrier family 20”家族 ...

2019年2月12日 · PiT1/SLC20A1 is an inorganic phosphate transporter with additional functions including the regulation of TNFα-induced apoptosis, erythropoiesis, cell proliferation and insulin signaling.

2022年5月23日 · We showed that patients with higher levels of SLC20A1 expression (SLC20A1high) exhibited poorer clinical outcomes in those with tumor stage I luminal A breast cancer. In addition, this SLC20A1high subgroup of patients exhibited less responses to endocrine therapy, specifically in those with the luminal A and luminal B subtypes of breast cancer.

2020年8月7日 · Our results suggest SLC20A1 is involved in human and zf urinary tract and urorectal development, and implicate SLC20A1 as a disease-gene for bladder exstrophy-epispadias complex (BEEC). Our study also provides early cell culture data to suggest that SLC20A1 variants found in patients affect cleaved caspase-3, consistent with a reported role of ...

2024年1月9日 · We reveal that Slc20a1 and Slc20a2 are differentially distributed in the hippocampus and associated with independent gene clusters, suggesting that they influence cognition by different mechanisms. Accordingly, using a combination of molecular, electrophysiological and behavioral analyses, we show that while PiT …