2024年12月25日 · SLC22A7 (Solute Carrier Family 22 Member 7) is a Protein Coding gene. Diseases associated with SLC22A7 include Gout and Bilirubin Metabolic Disorder. Among its related pathways are Transport of inorganic cations/anions and amino acids/oligopeptides and Fluoropyrimidine activity.

Solute carrier family 22 member 7 is a protein that in humans is encoded by the gene SLC22A7. [5] [6] [7] The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic.

2025年2月8日 · Nicotinic acid transport into human liver involves organic anion transporter 2 (SLC22A7). The role of OAT2-mediated hepatic uptake in determining the pharmacokinetics of several clinically important ECCS 1A drugs. The established OAT2 (SLC22A7)-substrate indomethacin showed a competitive interaction with cyclic nucleotide uptake.

Characterization of organic anion transporter 2 (SLC22A7): a highly efficient transporter for creatinine and species-dependent renal tubular expression. Drug Metab. Dispos 43:984–93 [ DOI ] [ PubMed ] [ Google Scholar ]

solute carrier family 22 (organic anion transporter), member 7 [Source:HGNC Symbol;Acc: 10971] NLT, OAT2. Chromosome 6: 43,263,432-43,273,276 forward strand. GRCh37:CM000668.1. This gene has 9 transcripts (splice variants) and 16 paralogues.

The SLC22A7 gene contains various SNPs including some nonsynonymous SNPs in the coding region (Srimaroeng et al., 2008; Xu et al., 2005). Mutations that decrease expression or function of OAT2 may lead to decreased concentrations of …

Biased expression in liver (RPKM 51.8) and kidney (RPKM 19.9). 该基因编码的蛋白质参与了有机阴离子的非钠依赖性转运和排泄，其中一些具有潜在毒性。 编码的蛋白质是一种完整的膜蛋白，似乎位于肾脏的基底外侧膜。 已经描述了编码不同亚型的选择性剪接转录物变体。 [RefSeq 提供，2008 年 7 月] The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic.

2024年3月1日 · Title: Nicotinic acid transport into human liver involves organic anion transporter 2 (SLC22A7). The role of OAT2-mediated hepatic uptake in determining the pharmacokinetics of several clinically important ECCS 1A drugs.

SLC22A7的详细信息，包括基因名称，代码，染色体位置，相互作用关系和通路，简述为由该基因编码的蛋白质是参与的有机阴离子，其中有一些是有潜在毒性的钠独立运输和排泄。 所编码的蛋白质是一种完整的膜蛋白并且似乎局限于肾脏的基底膜。 编码不同同种型的可变剪接转录物变体已有描述。 [由RefSeq的，2008年7月提供]

当前研究发现，SLC22A7基因存在12种不同的转录本和12种不同的蛋白质变体。 该基因暂未发现相关的转录本和蛋白质序列信息。 Structure of Schlafen13 reveals a new class of tRNA/rRNA- targeting RNase engaged in translational control. Lineage-specific biology revealed by a finished genome assembly of the mouse.