2021年1月22日 · The mitochondrial citrate carrier SLC25A1, also known as citrate transporter protein (CTP) or citrate/isocitrate carrier (CIC), is a mitochondrial membrane transporter encoded in the nucleus by the SLC25A1 gene located on chromosome 22q11.2.

2014年3月15日 · We have previously demonstrated that SLC25A1 (CIC) promotes tumorigenesis, while its inhibition blunts tumor growth. We now report that CIC is a direct transcriptional target of several p53 mutants. We identify a novel interaction between mutant p53 (mutp53) and the transcription factor FOXO-1 which is responsible for regulation of CIC ...

2018年4月12日 · We demonstrate that SLC25A1 plays a key role in maintaining the mitochondrial pool of citrate and redox balance in CSCs, whereas its inhibition leads to reactive oxygen species build-up thereby...

2021年1月22日 · The mitochondrial citrate/isocitrate carrier, CIC, has been shown to play an important role in a growing list of human diseases. CIC belongs to a large family of nuclear-encoded mitochondrial transporters that serve the fundamental function of allowing the transit of ions and metabolites through the …

2020年11月1日 · The human mitochondrial citrate carrier (CIC), also known as citrate transport protein (CTP), solute carrier family 25 member 1 (SLC25A1) or tricarboxylate carrier protein, is encoded by the gene SLC25A1.

2023年9月9日 · Here, we report the generation of mice with systemic overexpression (sTg) of SLC25A1 or SLC13A5. Both animals displayed increased cytosolic levels of citrate and acetyl-CoA; however, SLC13A5 sTg...

2023年11月19日 · The solute carrier family 25 member 1 (SLC25A1), originally known as citrate transporter protein (CTP) or mitochondrial citrate/isocitrate carrier (CIC), is encoded by the SLC25A1 gene located on chromosome 22q11.21 . It is the only identified human transporter for citrate in the mitochondrial membrane to date.

2014年3月16日 · The mitochondrial citrate transporter SLC25A1, also known as CIC or CTP, belongs to a family of proteins embedded in the inner mitochondrial membrane and promotes the efflux of tricarboxylic citrate to the cytoplasm in exchange for dicarboxylic cytosolic malate [11-13].

2023年7月18日 · Mechanistically, SLC25A1 loss results in a proliferation defect and activates two distinct senescence pathways, oncogene-induced senescence (OIS) and mitochondrial dysfunction-induced senescence (MiDAS), both involving the p53 tumor suppressor and driven by two discernible signals: the accumulation of 2HG, inducing OIS, and mitochondrial ...

The mitochondrial citrate carrier SLC25A1, or citrate/isocitrate carrier (CIC), is a member of the solute carrier (SLC) superfamily located in the inner mitochondrial membrane (Palmieri, 2013). It is the sole transporter mediating citrate or isocitrate exchange from mitochondria to the cytoplasm against malate (Peng et al, 2020).