2024年12月25日 · SLC27A2 (Solute Carrier Family 27 Member 2) is a Protein Coding gene. Diseases associated with SLC27A2 include Adrenoleukodystrophy and Lysosomal Storage Disease. Among its related pathways are Fatty acid metabolism and …

2019年4月17日 · PMN-MDSCs had a much higher expression of Slc27a2, which encodes FATP2. This was confirmed by quantitative PCR (qPCR) (Fig. 1a). No upregulation of other transporters and receptors involved in...

Long-chain fatty acid transport protein 2 is an enzyme that in humans is encoded by the SLC27A2 gene. [5] [6] The protein encoded by this gene is an isozyme of long-chain fatty-acid-coenzyme A ligase family.

2022年8月4日 · We found that specific upregulation of SLC27A2 could significantly inhibited the proliferation, migration, and invasion of renal cancer cell lines. SLC27A2 could also influence the...

2025年2月9日 · Upregulated SLC27A2/FATP2 in differentiated thyroid carcinoma promotes tumor proliferation and migration. Involvement of FATP2-mediated tubular lipid metabolic reprogramming in renal fibrogenesis. In overweight/obese pregnancies, the increased FATP2 placental expression could contribute to increased fatty acid delivery to the fetus.

2013年4月1日 · FATP2 is encoded by the SLC27A2 gene and expressed primarily in the liver and kidney (Fig. 2), but has also been shown to be present in trophoblasts of the human placenta (Krammer et al., 2011, Mishima et al., 2011, Steinberg et al., 1999). FATP2 is unique to other FATPs in that it has been shown to function as both a fatty acid transporter and ...

2025年2月8日 · Enables long-chain fatty acid transmembrane transporter activity; long-chain fatty acid-CoA ligase activity; and very long-chain fatty acid-CoA ligase activity. Acts upstream of or within fatty acid transport; long-chain fatty acid metabolic process; and very long-chain fatty acid catabolic process.

这种同功酶可激活长链、支链和超长链脂肪酸及其辅酶 A 衍生物中含有 22 个或更多碳原子的脂肪酸。 它主要在肝脏和肾脏中表达，并且存在于内质网和过氧化物酶体中，但不存在于线粒体中。 其降低的过氧化物酶体酶活性部分导致了 X 连锁肾上腺脑白质营养不良的生化病理学。 已发现该基因编码不同亚型的可变剪接转录物变体。 [RefSeq 提供，2009 年 4 月] The protein encoded by this gene is an isozyme of long-chain fatty-acid-coenzyme A Ligase family.

2025年2月8日 · SLC27A2 is required for the transcriptional induction of miR-411 in ovarian cancer. Reduced miR-411 expression contributes to ovarian cancer chemo-resistance. Contractile strength in FATP2-knockdown gallbladders was significantly greater than in control gallbladders following lithogenic diet administration.

2023年4月11日 · Solute carrier family 27 member 2 (SLC27A2) is important for FA transportation and metabolism and is related to cancer progression. This study aims to explore the mechanisms of how PPARs and SLC27A2 regulate FA metabolism in colorectal cancer (CRC) and find new strategies for CRC treatment.