NaPi2b/SLC34A2. 2b型钠依赖性磷酸盐转运体（NaPi-IIb）是一种多通道的膜蛋白，由690个氨基酸组成，是溶质载体SLC34家族的成员，该家族由NaPi-IIa（SLC34A1）、NaPi-IIb（SLC34A2）和NaPi-IIc（SLC34A3）构成。

2024年12月25日 · SLC34A2 (Solute Carrier Family 34 Member 2) is a Protein Coding gene. Diseases associated with SLC34A2 include Pulmonary Alveolar Microlithiasis and Testicular Microlithiasis. Among its related pathways are Transport of inorganic cations/anions and amino acids/oligopeptides and Disorders of transmembrane transporters.

2022年12月20日 · 2b型钠依赖性磷酸盐转运体（NaPi-IIb）是一种多通道的膜蛋白，由690个氨基酸组成，是溶质载体SLC34家族的成员，该家族由NaPi-IIa（SLC34A1）、NaPi-IIb（SLC34A2）和NaPi-IIc（SLC34A3）构成。

2020年1月31日 · Solute carrier family 34 member A2 (SLC34A2), also known as NaPi2b, is located on human chromosome 4p15.2 and it encodes a 690 amino acid protein, pH-sensitive sodium-dependent phosphate...

SLC34A2 encodes a type 2b sodium-dependent phosphate transporter, NaPi-IIb. It is a multi-pass membrane protein, composed of 690 amino acids. This protein has been reported to mediate transporting inorganic phosphate into epithelial cells via sodium ion co-transport and have a role in the synthesis of surfactants in lung alveoli [4].

We first identified a PAM locus by homozygosity mapping to 4p15, then identified, by a candidate-gene approach, the gene responsible for the disease as SLC34A2 (the type IIb sodium-phosphate cotransporter gene), which is involved in phosphate homeostasis in several organs.

2015年7月9日 · 此外，我们首次发现六种非小细胞肺癌细胞系中slc34a2的表达降低。我们的结果还揭示了 slc34a2 对几种 nsclc 细胞系的细胞生长、迁移和侵袭的显着抑制作用。 slc34a2还分别强烈抑制a549皮下肿瘤模型和肺转移模型中的肿瘤生长和转移能力。

The SLC34A2 gene provides instructions for making a protein called the type IIb sodium-phosphate cotransporter, which plays a role in the regulation of phosphate levels (phosphate homeostasis). Learn about this gene and related health conditions.

2025年2月8日 · SLC34A2 promotes cell proliferation by activating STX17-mediated autophagy in esophageal squamous cell carcinoma. New insights in the genetic variant spectrum of SLC34A2 in pulmonary alveolar microlithiasis; a systematic review.

该基因编码的蛋白质是一种 pH 敏感的钠依赖性磷酸盐转运蛋白。 在较低的 pH 值下磷酸盐吸收增加。 该基因的缺陷是肺泡微石症的一个原因。 已发现该基因编码两种不同亚型的三种转录变体。 [RefSeq 提供，2010 年 5 月] The protein encoded by this gene is a pH-sensitive sodium-dependent phosphate transporter. Phosphate uptake is increased at lower pH. Defects in this gene are a cause of pulmonary alveolar microlithiasis.