Dec 25, 2024 · SLC38A9 (Solute Carrier Family 38 Member 9) is a Protein Coding gene. Diseases associated with SLC38A9 include Lung Cancer and Epilepsy . Among its related pathways are PIP3 activates AKT signaling and Gene expression (Transcription) .

Feb 1, 2018 · 今日，Science刊登了一篇名为 “Lysosomal cholesterol activates mTORC1 via an SLC38A9–Niemann-Pick C1 signaling complex”的文章。来自加州大学伯克利分校的研究者发现，溶酶体胆固醇通过SLC38A9-NPC1复合体驱动mTORC1的活化和生长信号。

启用 L-精氨酸跨膜转运蛋白活性和 L-亮氨酸跨膜转运蛋白活性。 参与氨基酸跨膜转运；细胞对氨基酸刺激的反应；和 TOR 信号的正向调节。 位于晚期内体和溶酶体膜。 是溶酶体膜的组成部分。 与 Ragulator 复合体共定位。 [由基因组资源联盟提供，2022 年 4 月] Enables L-arginine transmembrane transporter activity and L-leucine transmembrane transporter activity.

Oct 19, 2017 · Activation of mTORC1 by arginine requires SLC38A9, a poorly understood lysosomal membrane protein with homology to amino acid transporters. Here, we validate that SLC38A9 is an arginine sensor for the mTORC1 pathway, and we uncover an unexpectedly central role for SLC38A9 in amino acid homeostasis.

Jan 7, 2015 · Here we describe the uncharacterized human member 9 of the solute carrier family 38 (SLC38A9) as a lysosomal membrane-resident protein competent in amino acid transport. Extensive functional...

Mar 24, 2017 · The lysosomal transmembrane protein, SLC38A9, is required for mTORC1 activation by cholesterol through conserved cholesterol-responsive motifs. Moreover, SLC38A9 enables mTORC1 activation by cholesterol independently from its arginine-sensing function.

Mar 26, 2015 · Here we describe the uncharacterized human member 9 of the solute carrier family 38 (SLC38A9) as a lysosomal membrane-resident protein competent in amino acid transport. Extensive functional proteomic analysis established SLC38A9 as an integral part of the Ragulator-RAG GTPases machinery.

在此项研究中，研究者证实SLC38A9是mTORC1途径的精氨酸传感器，并且发现SLC38A9在调节氨基酸平衡中有意想不到的中心作用。 SLC38A9以精氨酸调节的方式介导溶酶体中许多必需氨基酸的转出，其中包括mTORC1通过胞质Sestrin蛋白感应的亮氨酸。

Jan 7, 2015 · Here, we identify SLC38A9, an uncharacterized protein with sequence similarity to amino acid transporters, as a lysosomal transmembrane protein that interacts with the Rag guanosine triphosphatases (GTPases) and Ragulator in an amino acid–sensitive fashion.

Jan 5, 2025 · SLC38A9 is a physical and functional component of the amino acid sensing machinery that controls the activation of mTOR; SLC38A9 functions upstream of the Rag GTPases and is an excellent candidate for being an arginine sensor for the mTORC1 pathway.