2023年8月19日 · Brain exposure of systemically administered biotherapeutics is highly restricted by the blood-brain barrier (BBB). Here, we report the engineering and characterization of a BBB transport...

2016年2月2日 · Using a transcriptomic and proteomic approaches they identify three new novel targets for bispecific antibodies that are able to get through the BBB by a receptor-mediated transcytosis pathway. The best of these three is CD98 (SLC3A2) that forms a heterodimer with LAT1 (SLC7A5) at the BBB.

Here, we report the engineering and characterization of a BBB transport vehicle targeting the CD98 heavy chain (CD98hc or SLC3A2) of heterodimeric amino acid transporters (TV). The pharmacokinetic and biodistribution properties of a CD98hc antibody transport vehicle (ATV) are assessed in humanized CD98hc knock-in mice and cynomolgus monkeys.

Inhibition of the heterodimeric amino acid carrier SLC7A5/SLC3A2 (LAT1/CD98) has been widely studied in tumor biology but its role in physiological conditions remains largely unknown. Here we show that the SLC7A5/SLC3A2 heterodimer is constitutively present at different stages of erythroid differentiation but absent in mature erythrocytes.

2019年10月1日 · Here we show that BCAA and AAA shortage phenocopies the inhibition of mTORC1 signalling, protein synthesis and cell proliferation caused by CD98hc ablation. Furthermore, our data indicate that...

2023年4月29日 · Here we report bispecific antibody shuttles that engage CD98hc (also known as 4F2 and SLC3A2), the heavy chain of the large neutral amino acid transporter (LAT1), and efficiently transport IgGs into the brain parenchyma.

2004年12月29日 · CD98 heterodimers, comprised of a heavy chain (CD98hc, SLC3A2) and one of several light chains, interact with integrins through CD98hc. CD98hc overexpression leads to anchorage-independent cell growth and tumorigenesis in 3T3 fibroblasts and activates certain integrin-regulated signaling pathways.

2022年5月23日 · 嗜神经病毒是对神经组织具有亲和力的病毒，已经利用它开发出了许多进入大脑的策略，包括通过进入免疫细胞内实现跨BBB（5b）、 直接跨 BBB 胞吞（5a）或通过外周或感觉神经绕过BBB (5c)（图5） 一些病毒不仅可以感染大脑也可以感染CNS细胞。

2020年7月22日 · Our study further found that: 1) INSR, IGF1R, LRP1 and LRP8 were enriched in the mouse BMVs compared to peripheral tissues; and INSR was enriched in human BMVs compared to total brain and lung; 2) SLC2A1/GLUT1, LRP-1, SLC3A2/CD98hc and CDC50A were the most abundant among receptor/transporters studied in human BMVs; whereas SLC2A1/GLUT1, LRP-1 ...

The blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCSFB) separate the brain and cerebrospinal fluid (CSF) from the systemic circulation and represent a barrier to the uptake of both endogenous compounds and xenobiotics into ...