2024年12月25日 · SLC44A4 (Solute Carrier Family 44 Member 4) is a Protein Coding gene. Diseases associated with SLC44A4 include Deafness, Autosomal Dominant 72 and Rare Autosomal Dominant Non-Syndromic Sensorineural Deafness Type Dfna.

2022年10月13日 · ihc 研究显示 slc44a4 在几种肿瘤中的表达上调，包括 85% 的原发性 pca。在分化较差的肿瘤中证明了其较高的表达。体内研究揭示了 slc44a4 定向抗体在雄激素依赖性和非依赖性肿瘤异种移植物中的抗肿瘤活性。asg-5me 靶向 slc44a4 的 adc药物. 靶向slc44a4的adc临床进展

Choline transporter-like protein 4 is a protein that in humans is encoded by the SLC44A4 gene. [5] [6] [7]

2016年11月1日 · Here, we describe the expression of SLC44A4 in pancreatic and prostate cancers and report on the preclinical development of ASG-5ME, an ADC composed of an SLC44A4-specific human IgG2 antibody conjugated with monomethyl auristatin E (MMAE) through a protease cleavable valine-citruline linker.

slc44a4，即溶质载体家族44成员4，别名ctl4、ng22、tppt、dfna72、htppt1、c6orf29。它是一种由人类slc44a4基因编码的跨膜蛋白，属于slc44家族。slc44a4在多种组织中表达，尤其在结肠、胃和其他组织中表达较高。

Purpose ASG-5ME is an antibody-drug conjugate (ADC) targeting SLC44A4, a novel cell surface target expressed on most pancreatic and gastric cancers. This first-in-human study of ASG-5ME evaluated safety, pharmacokinetics, and preliminary activity of ASG-5ME in advanced pancreatic and gastric cancer …

2025年2月8日 · Whole-exome sequencing revealed SLC44A4, which encodes the choline transport protein, as the pathogenic gene in this family. In the zebrafish model, downregulation of slc44a4 using morpholinos led to significant abnormalities in the zebrafish inner ear and lateral line neuromasts and contributed, to some extent, to disabilities in hearing and ...

该基因编码的蛋白质可能是一种钠依赖性跨膜转运蛋白，参与胆碱能神经元对胆碱的摄取。 该基因的缺陷会导致唾液酸贮积症，这是一种溶酶体贮积病。 已发现该基因的三个转录变体编码不同的亚型。 [RefSeq 提供，2010 年 5 月] The protein encoded by this gene may be a sodium-dependent transmembrane transport protein involved in the uptake of choline by cholinergic neurons. Defects in this gene can cause sialidosis, a lysosomal storage disease.

SLC44A1 is widely expressed throughout the nervous system in both neurons and oligodendrocytes, while SLC44A2-4 are mainly detected in peripheral tissues. The subcellular localization of the proteins was mainly addressed for SLC44A1 through the development of specific antibodies.

ASG-5ME, an SLC44A4-targeting antibody carrying monomethyl auristatin E (MMAE), a microtubule-disrupting agent, was investigated in men with metastatic castration resistant prosta …