2024年12月25日 · SLC8A1 (Solute Carrier Family 8 Member A1) is a Protein Coding gene. Diseases associated with SLC8A1 include Cardiovascular System Disease and Megacolon. Among its related pathways are Transport of inorganic cations/anions and amino acids/oligopeptides and Cardiac conduction.

slc8a1，也被称为钠钙交换蛋白1（ncx1），是溶质载体家族8的成员。这种蛋白在细胞内钙离子（ca²⁺）的调节中扮演着重要角色。它通过钠离子（na⁺）和钙离子之间的交换来调控细胞内的钙离子水平，这对于细胞的正常功能和信号传导至关重要。 slc8a1的表达模式

2025年2月8日 · There is a functional role of sodium-calcium exchanger SLC8A1 in human atrial and atrioventricular nodal conduction as suggested by genetically modified mouse models.

SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline 10, 11, 12. Required for normal embryonic heart development and the onset of heart contractions (By similarity).... show …

There is a functional role of sodium-calcium exchanger SLC8A1 in human atrial and atrioventricular nodal conduction as suggested by genetically modified mouse models. human osteoblasts and osteoblasts from Ano6(-/-) and WT mice, we demonstrate that NCX1 requires Ano6 to efficiently translocate Ca(2+) out of osteoblasts into the calcifying bone ...

2020年6月22日 · Here, we show that the Na+/Ca2+ exchanger 1 (NCX1, also known as solute carrier family 8 member A1 [SLC8A1]) plays a critical role in HS-triggered Na+ influx, concomitant Ca2+ efflux, and subsequent augmented NFAT5 accumulation.

关于 slc8a1 Cytogenetic location: 2p22.1 Genomic coordinates (GRCh38): 2:40,097,270-40,512,435 (from NCBI) This gene has 19 transcripts (splice variants), 287 orthologues and 7 paralogues.

以组织特异性方式表达三个哺乳动物基因（SLC8A1， SLC8A2 和 SLC8A3）及其剪接变体，以介导跨细胞膜的Ca 2 + -通量，因此在调节Ca 2+ 依赖性事件中起重要作用。 许多细胞类型。 一种长通缉线粒体的Na + /钙 2+ 交换器最近已被确定为蛋白质NCLX，代表的基因产物 SLC8B1。 不同的NCX同工型/剪接变体导致兴奋-收缩偶联，大脑和学习的长期增强，血压调节，免疫反应，神经递质和胰岛素分泌，线粒体生物能学等。 NCX蛋白表达和调节的改变导致畸变。 Ca 2 +- 心力 …

2024年12月18日 · 北京大学人民医院的Wang Jian liu教授团队在本刊发表了题为“Traction force with extracellular matrix mediated by cytoskeleton influences metastasis through SLC8A1 induced Wnt-β-catenin pathway in endometrial cancer”的研究快讯，揭示了细胞牵引力在子宫内膜癌进展中的作用，并确定了SLC8A1作为 ...

与人类SLC8A1 (溶质载体家族8成员A1)正交。 [由基因组资源联盟，2022年4月提供] 该基因暂未发现相关的转录本和蛋白质序列信息。 A tissue-specific atlas of mouse protein phosphorylation and expression. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). The transcriptional landscape of the mammalian genome. 激活ankyrin结合活性；钙：钠抗泵活性；和跨膜转运体结合活性。