Sialyl Lewis (a) (sLe (a)), also termed CA19-9 antigen, is recognized by murine mAb19-9 and is expressed on the cancer cell surface as a glycolipid and as an O-linked glycoprotein.

2023年10月2日 · Sialyl Lewisa (sLea), also known as cancer antigen 19-9 (CA19-9), is a tumor associated carbohydrate antigen. The overexpression of sLea on the surface of a variety of cancer cells makes it an attractive target for anti-cancer immunotherapy. However, sLea based anticancer vaccines have been under-explored.

2023年10月2日 · Sialyl Lewis a (sLe a), also known as cancer antigen 19-9 (CA19-9), is a tumor-associated carbohydrate antigen. The overexpression of sLe a on the surface of a variety of cancer cells makes it an attractive target for anticancer immunotherapy. However, sLe a -based anticancer vaccines have been under-explored.

Sialyl Lewisa (sLea), also termed CA19-9 antigen, is recognized by murine mAb19-9 and is expressed on the cancer cell surface as a glycolipid and as an O-linked glycoprotein. It is highly expressed in a variety of gastrointestinal epithelial ...

2009年3月1日 · We describe here for the first time the total synthesis of pentenyl glycoside of sLe (a) hexasaccharide and its conjugation to KLH to construct a sLe (a)-KLH conjugate. Groups of five mice were...

Finally, the survival analysis suggested that sLe (a) expression may be a prognostic factor for predicting disease-free survival in colorectal cancer (p=0.012). The glycoconjugates expressed by cancer cells frequently contain sialylated oligosaccharide chains.

2023年10月3日 · Sialyl Lewis^a (sLe^a ), also known as cancer antigen 19-9 (CA19-9), is a tumor-associated carbohydrate antigen. The overexpression of sLe^a on the surface of a variety of cancer cells makes it an attractive target for anticancer immunotherapy. However, sLe^a …

Finally, the sLea-MMCCH and the thiolated KLH were linked in a buffered solution to furnish the sLea-KLH conjugate. The sLea concentration and sLea/KLH epitope ratio of the sLea conjugate were determined using resor-cinol by measuring sialic acid content of sLea and KLH by a dye binding method (BioRad, Dye reagent) to be 874.

方法采用免疫组化法检测78例肝癌组织中E-selectin、sLeX、sLeA、CD44v6的表达情况,收集统计患者的临床特征资料,分别比较在各种临床特征中E-selectin、sLeX、sLeA、CD44v6的表达差异。 结果 E-selectin在癌灶边缘血管内皮细胞中的阳性率为70.51%,与病理分级、门脉癌栓、肝外转移、卫星灶、术后3个月内复发相关,与患者生存期、肿瘤大小、血清甲胎蛋白 (alpha fetoprotein,AFP)水平无明显相关。 sLeX和sLeA在肝细胞癌肿瘤细胞中的表达阳性率分别为64.10%和69.23%,与 …

Sialyl Lewisa 是一种有吸引力的碳水化合物相关癌症抗原。 为了开发一种有效的唾液酸 Lewis疫苗，完成了唾液酸 Lewis一种四糖的立体选择性合成。 该聚糖与强大的载体噬菌体 Qβ 共价偶联，可诱导更高水平的和持续的抗唾液酸 Lewisa IgG 抗体反应，从而在小鼠转移性癌症模型中提供显著的肿瘤保护。 is an attractive carbohydrate-associated cancer antigen. To develop an effective sialyl Lewis based vaccine, the stereoselective synthesis of sialyl Lewis tetrasaccharide was …