Smad2 Positively Regulates the Generation of Th17 Cells,
2010年9月1日 · In the experimental autoimmune encephalomyelitis model, Smad2 deficiency in T cells significantly ameliorated disease severity and reduced generation of Th17 cells. …
SMAD2 is essential for TGF beta-mediated Th17 cell generation
2010年9月17日 · We show here that SMAD2 is essential for Th17 cell differentiation and that it acts in part by modulating the expression of IL-6R on T cells.
SMAD2 Is Essential for TGFβ-mediated Th17 Cell Generation
The diminution in IL-17 production by CD4 + T cells correlates with accelerated loss of Il6ra expression and a corresponding decrease in STAT3 activation in Smad2-deficient T cells, …
Smad2 positively regulates the generation of Th17 cells
2010年9月17日 · In the experimental autoimmune encephalomyelitis model, Smad2 deficiency in T cells significantly ameliorated disease severity and reduced generation of Th17 cells. …
Phosphorylation status determines the opposing functions of Smad2…
2015年7月21日 · Here we show that the highly homologous TGF-β receptor-regulated Smads (R-Smads): Smad2 and Smad3 oppositely modify STAT3-induced transcription of IL-17A and …
ADAM9 enhances Th17 cell differentiation and autoimmunity by ... - PNAS
2021年4月28日 · In this study, we reveal that ADAM9 is specifically expressed in Th17 cells and promotes their differentiation by activating TGF-β1 and promoting SMAD2/3 phosphorylation. …
Smad2 Positively Regulates the Generation of Th17 Cells - PMC
In the experimental autoimmune encephalomyelitis model, Smad2 deficiency in T cells significantly ameliorated disease severity and reduced generation of Th17 cells. Furthermore, …
Trim33 mediates the proinflammatory function of Th17 cells
2018年7月2日 · Here, we report that tripartite motif-containing 33 (Trim33), a modulator of TGF-β signaling that associates with Smad2, regulates the proinflammatory function of Th17 cells. …
磷酸化状态决定了Smad2 / Smad3作为TH17分化中STAT3 ... - X …
Here we show that the highly homologous TGF-β receptor-regulated Smads (R-Smads): Smad2 and Smad3 oppositely modify STAT3-induced transcription of IL-17A and retinoic acid …
SMAD2 Is Essential for TGFβ-mediated Th17 Cell Generation
The diminution in IL-17 production by CD4 + T cells correlates with accelerated loss of Il6ra expression and a corresponding decrease in STAT3 activation in Smad2-deficient T cells, …
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