Mothers against decapentaplegic homolog 3 - Wikipedia
SMAD3-knockout mouse is a legitimate animal model of human aneurysms‐osteoarthritis syndrome (AOS), also named Loeys-Dietz Syndrome (type 3). SMAD3 deficiency promotes …
SMAD3 Gene - GeneCards | SMAD3 Protein | SMAD3 Antibody
2024年12月25日 · SMAD3 (SMAD Family Member 3) is a Protein Coding gene. Diseases associated with SMAD3 include Loeys-Dietz Syndrome 3 and Aortic Aneurysm. Among its …
SMAD3 gene - MedlinePlus
The SMAD3 gene provides instructions for making a protein involved in transmitting chemical signals from the cell surface to the nucleus. This signaling pathway, called the transforming …
Multiomic characterization, immunological and prognostic …
2025年1月3日 · SMAD3 is a pivotal transcription factor that modulates the transforming growth factor-beta (TGF-β) signal and assumes a dual role in both restraining and promoting cancer. …
SMAD 家族成员 3（SMAD3）基因 | MCE - MCE-生物活性分子大师
SMAD 蛋白家族是一组细胞内信号转导蛋白，类似于果蝇基因“母亲抗脑瘫” (Mad) 和秀丽隐杆线虫基因 Sma 的基因产物。 SMAD3 蛋白在转化生长因子-β信号通路中起作用，将信号从细胞表 …
Smad2 and Smad3 have differential sensitivity in relaying TGFβ ...
2016年2月24日 · Smad2 and Smad3 are structurally similar and it is mostly considered that they are equally important in mediating TGFβ signals. Here, we show that Smad3 is an insensitive …
SMAD3 SMAD family member 3 [ (human)] - National Center for ...
The SMAD3 protein functions in the transforming growth factor-beta signaling pathway, and transmits signals from the cell surface to the nucleus, regulating gene activity and cell …
Smad3 is essential for polarization of tumor-associated ... - Nature
2023年3月31日 · The role of Smad3 in regulating neutrophil recruitment and polarization in lung cancer was investigated in wild-type (Smad3-WT) and Smad3-knockout (Smad3-KO) mice …
A positive feedback loop between SMAD3 and PINK1 in …
4 天之前 · Intriguingly, SMAD3 positively transactivates PINK1 transcription independent of the canonical TGFβ signaling components, such as TGFβ-R1, SMAD2 or SMAD4. Second, we …
SMAD3 与 PINK1 正反馈调控线粒体自噬：解锁神经退行性疾病新 …
3 天之前 · smad3 促进线粒体自噬：由于 smad3 对 pink1 表达具有正向调控作用，研究人员进一步探究其对 pink1 依赖的线粒体自噬的影响。实验发现，smad3 抑制剂 e - sis3 预处理或 …