2024年12月25日 · SMAD4 (SMAD Family Member 4) is a Protein Coding gene. Diseases associated with SMAD4 include Myhre Syndrome and Juvenile Polyposis Syndrome. Among …

SMAD4, also called SMAD family member 4, Mothers against decapentaplegic homolog 4, or DPC4 (Deleted in Pancreatic Cancer-4) is a highly conserved protein present in all metazoans. …

The SMAD4 gene provides instructions for making a protein involved in transmitting chemical signals from the cell surface to the nucleus. The SMAD4 protein is part of a signaling pathway, …

2021年6月18日 · SMAD4 immunohistochemistry shows loss of nuclear expression in tumor cells, confirming the diagnosis. A patient presents with hernia sac mass, resection of which showed …

2025年3月1日 · Understanding SMAD4's role in immune cells is crucial, as its dysregulation can lead to autoimmune disorders, chronic inflammation, and immune deficiencies. The review …

Smad4 or DPC4 belongs to a family of signal transduction proteins that are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to transforming …

2018年2月2日 · Here we provide evidence that SMAD4, a core component of the canonical TGF-β signaling pathway, regulates the canonical TGF-β signaling pathway in porcine granulosa …

2009年1月9日 · Smad4 is an important mediator of signaling by TGFβ family members that is presumed to be controlled by the phosphorylation status of its partners, the receptor-regulated …

The SMAD4 gene encodes a protein involved in signal transduction of the transforming growth factor-beta (see, e.g., TGFB1, 190180) superfamily and bone morphogenic proteins (see, e.g., …

2025年2月20日 · Title: SMAD4 mutations causing Myhre syndrome are under positive selection in the male germline. Investigating the impact of SMAD2 and SMAD4 downregulation in …