2024年12月25日 · SMAD5 (SMAD Family Member 5) is a Protein Coding gene. Diseases associated with SMAD5 include Fibrodysplasia Ossificans Progressiva and Pulpitis. Among its related pathways are TGF-beta receptor signaling in skeletal dysplasias and TGF-Beta Pathway.

2024年11月22日 · Smad5 (small mothers against decapentaplegic 5) protein is a receptor-regulated member of the Smad family proteins, mainly participating in the bone morphogenetic protein (BMP) signaling pathway in its phosphorylated form.

2017年8月15日 · A recent study by Fang et al. in Cell Research adds to this biological complexity by demonstrating an atypical cytoplasmic role for SMAD5 in modulating the bioenergetic homeostasis (i.e.,...

2017年7月4日 · Together, our findings indicate that Smad5 acts as a pHi messenger and maintains the bioenergetic homeostasis of cells by regulating cytoplasmic metabolic machinery. Given that most biological...

SMAD5 (dwarfin C, JV5-1, MAD5) 是一种受体激活的 Smad (R-Smad)，属于 dwarfin/SMAD 家族。SMAD5 蛋白受到 I 型 TGF-β 受体激活，而与 SMAD4 结合形成三聚体活性形式。SMAD5 参与 BMP 信号通路，调控成骨过程，与胚胎发育有关。

2024年11月22日 · Smad5 (small mothers against decapentaplegic 5) protein is a receptor-regulated member of the Smad family proteins, mainly participating in the bone morphogenetic protein (BMP) signaling pathway in its phosphorylated form. This article will provide a detailed review of Smad5, focusing on its gene ch …

We identified SMAD5 as direct target of miR-145, the suppressed expression of which consequently led to increased cell proliferation and migration/invasion. Smad5 acts as a intracellular pH messenger and maintains the bioenergetic homeostasis of cells by regulating cytoplasmic metabolic machinery.

2004年5月1日 · Smad5 belongs to the receptor-activated Smad that function as intracellular signal transducers for transforming growth factor-β superfamily. Smad5 protein is composed of N-terminal domain responsible for DNA-binding, C-terminal domain primarily required for protein-protein interactions, and the linker region containing motif essential for ...

SMAD5 是一种受体激活的 Smad (R-Smad)，也称为 dwarfin C, JV5-1 和 MAD5，属于 dwarfin/SMAD 家族。 SMAD5 蛋白由负责 DNA 结合的 N端结构域、主要用于蛋白质-蛋白质相互作用的 C 端结构域和包含泛素化降解所必需的基序的连接区组成。

2025年2月8日 · Smad5 determines murine amnion fate through the control of bone morphogenetic protein expression and signalling levels; Association of runx2 with smad 5 is essential for osteogenic induction of C2C12 cells; overexpression of Smurf1 specifically promotes Smad1 and Smad5 ubiquitination and degradation in embryonic lung epithelium