SMAD7 Gene - GeneCards | SMAD7 Protein | SMAD7 Antibody
2024年12月25日 · SMAD7 (SMAD Family Member 7) is a Protein Coding gene. Diseases associated with SMAD7 include Colorectal Cancer 3 and Breast Cancer. Among its related …
Regulation of TGF-beta signaling by Smad7 - PubMed
Inhibitory Smads, including Smad6 and Smad7, are key regulators of TGF-beta/bone morphogenetic protein (BMP) signaling by negative feedback loops. They can form stable …
Identification of Smad7, a TGFβ-inducible antagonist of TGF-β ...
1997年10月9日 · Transfection of Smad7 blocks responses mediated by TGF-β in mammalian cells, and injection of Smad7 RNA into Xenopus embryos blocks activin/TGF-β signalling. …
Expression and function of Smad7 in autoimmune and …
2021年5月31日 · In this review, we discuss advances in research of Smad7, a member of the I-Smads family and a negative regulator of TGF-β signaling, and mainly review the expression …
Current perspectives on inhibitory SMAD7 in health and disease
SMAD7, one of the I-SMADs, is an essential negative regulator of the pleiotropic TGF-β and bone morphogenetic protein (BMP) signaling pathways. In a negative feedback loop, SMAD7 …
Smad7非依赖TGF-β通路调控干细胞多能性的新机制_光谱网
9月5日，浙江大学生命科学研究员冯新华教授课题组在PNAS杂志在线发表了题为“Smad7 enables STAT3 activation and promotes pluripotency independent of TGF-β signaling”的研究论文，揭 …
Smad7:β-catenin complex regulates myogenic gene transcription
2019年5月16日 · Reporter gene analysis and chromatin immunoprecipitation demonstrated that Smad7 and β-catenin are cooperatively recruited to the extensively characterized ckm …
SMAD7 SMAD family member 7 [ (human)] - National Center for ...
Smad7 over-expression inhibits Smad2/3 phosphorylation, and decreases the expression of collagen I and alpha-SMA in HSC-T6 cells induced by TGF-beta1 to inhibit the progression of …
SMAD7 expression in CAR-T cells improves persistence and
2024年1月4日 · Here, we coexpressed SMAD7, a suppressor of TGF-β signaling, with a HER2-targeted CAR in engineered T cells. These novel CAR-T cells displayed high cytolytic efficacy …
Smad7 Protein Interacts with Receptor-regulated Smads (R …
Smad7 oligomerized with R-Smad proteins upon TGF-β signaling and directly inhibited R-Smad activity, as assessed by Gal4-luciferase reporter assays. Mechanistically, Smad7 competes …
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