2 天之前 · 上述研究阐释了arf蛋白在囊泡分裂过程中的分子机制，填补了最后阶段囊泡分裂的关键机制信息缺失，为细胞内物质运输的调控研究提供了新思路。 3月21日，相关研究成果以 …

The small ADP ribosylation factor (Arf) GTP-binding proteins are major regulators of vesicle biogenesis in intracellular traffic. [1] They are the founding members of a growing family that …

The ARF small GTPases play central roles in these mechanistic steps for multiple intracellular pathways. A molecular understanding of how ARF proteins act in coat recruitment and vesicle …

2006年5月1日 · The ADP-ribosylation factor (ARF) small GTPases regulate vesicular traffic and organelle structure by recruiting coat proteins, regulating phospholipid metabolism...

1 天前 · ADP-Ribosylation Factor (ARF) small GTPases have been found to act in vesicle fission through a direct ability to tubulate membrane. We have pursued cryoelectron microscopy (EM) …

2024年12月10日 · Here, we report that the ARF-like GTPase TITAN5 (TTN5) interacts with the large cytoplasmic variable region and protein-regulatory platform of IRT1. Heterozygous ttn5-1 …

当对ARF晶格中蛋白结合界面的关键残基引入突变时，虽然ARF1与包被蛋白复合物（coatomer）的结合未受影响，但囊泡的分裂过程却明显受阻。 这一结果印证了此前的研 …

2014年1月1日 · Small GTP-binding proteins of the ADP-ribosylation factor (Arf) family are key components of trafficking vesicles. In the past three decades a number of vesicular carriers, …

Here, this review particularly focuses on the self-assembly processes of Rab- and Arf-family small GTPases in intracellular membrane trafficking and thus summarizes the current experimental …

2025年3月17日 · These include Arf members (Arl1, Arf1), Arf GEFs (Sed4, Sec7), other classes of organelle dynamics regulators such as Rab GTPases (Ypt31, Sec4), and proteins involved …