2023年2月15日 · Small HDLs are potent promoters of macrophage cholesterol efflux by ATP-binding cassette transporter A1 (ABCA1), the first key step in cholesterol export 7, whereas large HDLs promote cholesterol...

Particle Numbers of Large vs. Small HDL. HDL particles are highly heterogeneous in structure, composition, metabolism, and function. Distinct HDL subpopulations might, therefore, exert differential effects on atherosclerosis (Camont et al., 2011). As a consequence, plasma concentrations of specific HDL subpopulations can be hypothesized to ...

2023年10月9日 · Low number of small HDL particles are associated with increased hazard of sepsis, sepsis-related death, and sepsis-related critical care admission. However, genetic analyses did not strongly support this as causal.

2022年12月25日 · 核磁共振(nmr)波谱允许测量hdl颗粒计数，并允许根据颗粒大小进行分类。 近日，心 血管 领域权威杂志Cardiovasc Res上发表了一篇研究文章，研究人员旨在评估较低的不同亚组分HDL的数量与感染性疾病发病率和死亡率增加之间的相关性。

2023年5月2日 · In multifactorial adjusted analyses, low number of small and medium HDL particles was associated with increased risk of any infection and infectious disease-related death, whereas low number of large and extra-large HDL particles was not.

2016年9月2日 · Lipid-poor and small HDL displayed both high capacity for ABCA1-mediated cholesterol efflux and strong anti-inflammatory action, whereas the larger particles showed stronger antioxidant function.

2015年3月27日 · In this issue, Du et al 10 challenge this notion by providing strong evidence that small, dense HDL particles are potent acceptors of cholesterol exported from macrophages by the ABCA1 pathway. Moreover, they show that the major mediator of cholesterol export from macrophages to HDL is ABCA1.

2013年10月3日 · HDL subpopulations can be distinct in their biological function; small, dense HDL3, which are enriched in bioactive lipids and proteins 8, 14 and display distinct structure, 15, 16 possess potent capacity to efflux cellular cholesterol via the ATP-binding cassette transporter A1 (ABCA1), 17 to protect low-density lipoprotein (LDL) from oxidative...

2022年12月20日 · Low levels of HDL cholesterol have been associated with increased risk of infectious disease morbidity and mortality. Nuclear magnetic resonance (NMR) spectroscopy permits the measurement of HDL particle count and allows further subclassification according to …

2024年12月11日 · High-density lipoproteins (HDL) exist in various subclasses, with smaller HDL particles possessing the highest anti-oxidative and anti-inflammatory properties. Understanding the role of these specific subclasses in chronic kidney disease (CKD) could provide valuable insights into disease progression and potential therapeutic targets.