2015年4月1日 · Small heat shock proteins (sHsps) are conserved across species and are important in stress tolerance. Many sHsps exhibit chaperone-like activity in preventing aggregation of target proteins, keeping them in a folding–competent state and refolding them by themselves or in concert with other ATP-dependent chaperones.

2020年4月16日 · Small heat shock proteins (sHSPs) are an ubiquitous protein family found in archaea, bacteria and eukaryotes. In plants, as in other organisms, sHSPs are upregulated by stress and are proposed to act as molecular chaperones to protect other proteins from stress-induced damage. sHSPs share an ‘α-crystallin domain’ with a β-sandwich ...

2023年1月23日 · Here we show that cytosolic small heat shock proteins are imported under basal conditions into the mitochondrial intermembrane space, where they operate as molecular chaperones. Protein...

2022年6月15日 · Plants respond to various stresses by triggering the expression of genes that encode proteins involved in plant growth, fruit ripening, cellular protein homeostasis, and tolerance systems. sHSPs, a subfamily of heat shock proteins (HSPs), can be expressed in plants to inhibit abnormal aggregation of proteins and protect normal proteins by intera...

Small heat shock proteins are a rather heterogeneous family of ATP-independent chaperones, some of which have been proven to block protein aggregation and help the cells to survive stressful conditions. Although much less studied than high molecular weight HSPs like HSP70/HSPA or HSP90/HSPC, their i …

2016年6月13日 · sHSPdb (small Heat Shock Proteins database) is an integrated resource containing non-redundant, full-length and curated sequences of sHSP, classified on the basis of amino acids motifs and physico-chemical properties. sHSPdb gathers data about sHSP defined by various databases (Uniprot, PFAM, CDD, InterPro).

2019年2月13日 · Small Heat Shock Proteins (sHSPs) are ATP-independent molecular chaperones conserved across species, and expressed throughout the kingdoms of life from archaea to humans (Bult et al. 1996; Caspers et al. 1995; Eyles and Gierasch 2010; Richter et al. 2010). sHSPs form dynamic oligomeric complexes that can exchange subunits and can dissociate ...

2017年10月1日 · Small heat shock proteins (sHsps) are a group of proteins, which express ubiquitously from prokaryotes to eukaryotes. Small Hsps are structurally different from other Hsps due to their lesser nucleotide and amino acid sequence conservation.

2010年9月16日 · We identified four small Hsp genes (Hsp22, Hsp67Bc, Hsp67Ba and Hsp67Bb) that may influence developmental stability and/or canalization, possibly through multiple buffering mechanisms. Our findings provide new insights into the endogenous roles of these heat shock genes, and contribute to the understanding of the molecular mechanisms ...

Small heat shock proteins (sHSPs) associate with nuclei, cytoskeleton and membranes, and as molecular chaperones they bind partially denatured proteins, thereby preventing irreversible protein aggregation during stress. sHSP monomers consist of a conserved alpha-crystallin domain of approximately 90 …