Small RNA (sRNA) are polymeric RNA molecules that are less than 200 nucleotides in length, and are usually non-coding. [1] RNA silencing is often a function of these molecules, with the most common and well-studied example being RNA interference (RNAi), in which endogenously expressed microRNA (miRNA) or exogenously derived small interfering ...

2005年2月28日 · Eukaryotes produce various types of small RNAs of 19-28 nt in length. With rapidly increasing numbers of small RNAs listed in recent years, we have come to realize how widespread their functions are and how diverse the biogenesis pathways have evolved.

2022年4月12日 · The world of small noncoding RNAs (sncRNAs) is ever-expanding, from small interfering RNA, microRNA and Piwi-interacting RNA to the recently emerging non-canonical sncRNAs derived from longer...

2024年11月14日 · In celebration of Cell ’s 50th anniversary, this Review explores our current understanding of the most extensively studied regulatory ncRNAs—small RNAs and long non-coding RNAs (lncRNAs)—which have profoundly shaped the field of RNA biology and beyond.

2024年4月11日 · Small RNA-mediated gene regulation stands as a cornerstone process, intricately controlling gene expression across multiple tiers, encompassing transcriptional, post-transcriptional, and epigenetic modalities.

2008年4月21日 · A small number of microRNAs are expressed mainly in embryonic stem (ES) cells, and attention has naturally focused on their roles in maintaining the pleuripotent undifferentiated state, self ...

2005年2月1日 · Small RNAs constitute a family of regulatory non-coding RNAs of 19-28 nt in length, which are derived from double-stranded RNAs (dsRNAs). Small RNAs can induce gene silencing through specific base-pairing with the target molecules.

Small RNA guides—microRNAs, small interfering RNAs, and repeat-associated small interfering RNAs, 21 to 30 nucleotides in length—shape diverse cellular pathways, from chromosome architecture to stem cell maintenance.

Small RNAs are short (~ 18 to 30 nucleotides), non-coding RNA molecules that can regulate gene expression in both the cytoplasm and the nucleus via post-transcriptional gene silencing (PTGS), chromatin-dependent gene silencing (CDGS) or RNA activation (RNAa).

2023年9月1日 · Small non-coding RNAs (sncRNAs), such as microRNAs (miRNAs), small interfering RNAs (siRNAs), PIWI-interacting RNAs (piRNAs), and transfer RNA (tRNA)-derived small RNAs (tsRNAs), play essential roles in regulating various cellular and …