SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 is a protein that in humans is encoded by the SMARCA5 gene. [ 5 ] [ 6 ] Function

2024年12月25日 · SMARCA5 (SNF2 Related Chromatin Remodeling ATPase 5) is a Protein Coding gene. Diseases associated with SMARCA5 include Ewing Sarcoma and Microcephaly. …

2023年2月16日 · SMARCA5 is an ATP-dependent helicase that is able to slide nucleosomes and order nucleosome arrays in vitro to act as a “ruler.” 57 Genetic studies using gene deletion or …

This is the first description of a fusion between EWSR1 and a chromatin-reorganizing gene(SMARCA5) in Ewing sarcoma/PNET. SMARCA5 has a potential role in proliferation and …

2024年2月29日 · Here we show that, in a gene dosage-dependent manner, the hypomorphic allele of SMARCA5 (S5tg) can rescue not only the developmental arrest in hematopoiesis in …

2025年2月8日 · Smarca5 is a key regulator of global chromatin structure. Smarca5-NoRC complex has a role in heterochromatin formation and silencing of ribosomal gene transcription …

2024年8月5日 · We find that SMARCA5 is required to maintain aberrant chromatin accessibility for leukemogenesis and then promotes transcriptional activation of AKR1B1, an aldo/keto …

2023年1月15日 · Smarca5 (SNF2H) 和Smarca1 (SNF2L) 编码的两个蛋白是ISWI染色质重塑复合物中两个核心ATP酶组分，它们参与了多种ISWI相关亚复合物的形成，在DNA复制、DNA损 …

2023年2月16日 · Genetic models suggested that SMARCA5 was required for DNA-templated events including transcription, DNA replication, and DNA repair. We engineered a degron tag …

2024年5月28日 · 5月21日，中国科学院上海营养与健康研究所王兰研究组在《发育细胞》（Developmental Cell）上在线发表了题为SMARCA5 reprograms AKR1B1-mediated fructose …