Dec 25, 2024 · SMC6 (Structural Maintenance Of Chromosomes 6) is a Protein Coding gene. Diseases associated with SMC6 include Fanconi Anemia, Complementation Group F and Cornelia De Lange Syndrome. Among its related pathways are Transport of the SLBP independent Mature mRNA and Metabolism of proteins. An important paralog of …

Structural maintenance of chromosomes protein 6 is a protein that in humans is encoded by the SMC6 gene. [5][6] The SMC6 was discovered first in fission yeast as RAD18 (SMC6).

Jun 1, 2021 · Smc5/6复合体在真核生物中分布广泛且高度保守，在DNA损伤同源重组修复、DNA复制、端粒长度维持及胚胎发育中发挥重要作用。 本文系统介绍了Smc5/6复合体结构特征和生物学功能领域的相关进展，为深入研究Smc5/6复合体提供理论参考。 1. Biological Science and Biotechnology Research Center, Guangxi Academy of Sciences, Nanning, Guangxi, 530007, China; 2. Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.

Jun 20, 2024 · Smc5/6已进化出多种功能来调节基因组复制、DNA损伤修复和一系列病毒的外体DNA，如乙型肝炎病毒、 人类免疫缺陷病毒 和人类乳头瘤病毒。 Smc5/6如何在染色体和表观DNA控制中获得其独特功能尚不清楚。 Smc5/6的功能部分是由其独特的非SMC亚基 (NSEs；non-SMC元件)。 在分裂酵母和出芽酵母中，Smc5/6的研究比在其他生物体中更广泛，该复合体包含6个NSE亚基 (Nse1-6)。 Nse2亚基 (也称为Mms21)具有SUMO E3连接酶活性，而Nse1-3-4 …

Jun 18, 2024 · Here, we report cryo-EM structures of the budding yeast Smc5/6 complex in eight-subunit, six-subunit and five-subunit states. Structural maps throughout the entire length of these complexes reveal...

SMC蛋白复合物（Structural maintenance of chromosomes complex）是一类高度保守的具有ATP酶活性的多亚基复合物，对染色体的结构维持、DNA复制以及转录调控等均具有重要的作用。 在真核生物中，主要有三类SMC蛋白复合物：黏连蛋白（cohesin）、凝缩蛋白（condensin）以及SMC5/6复合物。 目前，人们对于前两种复合物的结构和功能有较为详细的了解: 黏连蛋白主要介导细胞分裂时姐妹染色体的粘连， 凝缩蛋白主要参与染色体的组装浓缩, 这两种复合物的高分辨 …

Apr 3, 2023 · Among the SMC complexes, Smc5/6 has dedicated roles in DNA repair and preventing a buildup of aberrant DNA junctions. In the present study, we describe the reconstitution of ATP-dependent DNA...

Jun 19, 2023 · Among the three types of SMC complexes in eukaryotes, cohesin and condensin fold the genome into different domains and structures, while Smc5/6 plays direct roles in promoting chromosomal...

Dec 9, 2011 · We report the first biochemical characterization of purified full-length Smc6. Smc6 is an ATP-regulated and conformation-sensitive DNA-binding protein. Smc6 has a clear preference for binding to single-stranded DNA substrates. Our results implicate Smc6 as a major DNA-targeting component of the Smc5–6 complex.

Jun 19, 2024 · Smc5/6复合物由Smc5、Smc6和六个非SMC元件（Nse1-6）8个亚基组成，但完整Smc5/6复合物的结构信息的缺失阻碍了对其多元化生物学功能的研究。 该团队利用杆状病毒昆虫表达体系制备了高度均一的蛋白复合物样品，采用冷冻电镜技术解析了酿酒酵母Smc5/6复合物的三 …