
SMURF2 Gene - GeneCards | SMUF2 Protein | SMUF2 Antibody
2024年12月25日 · SMURF2 (SMAD Specific E3 Ubiquitin Protein Ligase 2) is a Protein Coding gene. Diseases associated with SMURF2 include Breast Cancer and Dyschromatosis Symmetrica Hereditaria. Among its related pathways are Autodegradation of the E3 ubiquitin ligase COP1 and Gene expression (Transcription).
SMURF2 - Wikipedia
E3 ubiquitin-protein ligase SMURF2 is an enzyme that in humans is encoded by the SMURF2 gene which is located at chromosome 17q23.3-q24.1. [5] [6]
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 [ (human)]
2025年2月9日 · SMURF2 is a novel E3 ubiquitin ligase for KLF5 and negatively regulates KLF5 by targeting it for proteasomal degradation. RLIM directly binds to Smurf2, enhancing TGF-beta responsiveness in osteosarcoma U2OS cells. SMURF2-mediated protective ubiquitination of EGFR may be responsible for EGFR overexpression in certain tumors.
泛素连接酶表 | Cell Signaling Technology
smurf2 是一种会与 bmp 和 tgf-β 通路中的 smad 相互作用的 e3 泛素连接酶。 SMURF2 还通过泛素化 Mad2 来调节有丝分裂纺锤体检查点。 ( 99 , 100 )
SMURF2 predisposes cancer cell toward ferroptosis in GPX4
2023年11月27日 · Dramatic downregulation of GSTP1 is caused by SMURF2-mediated GSTP1 ubiquitination and degradation at early stages of ferroptosis. Intriguingly, GSTP1 acts in GPX4- and FSP1-independent manners by catalyzing GSH conjugation of 4-hydroxynonenal and detoxifying lipid hydroperoxides via selenium-independent GSH peroxidase activity.
SMURF2 predisposes cancer cell toward ferroptosis in GPX4
2023年12月7日 · Dramatic downregulation of GSTP1 is caused by SMURF2-mediated GSTP1 ubiquitination and degradation at early stages of ferroptosis. Intriguingly, GSTP1 acts in GPX4- and FSP1-independent manners by catalyzing GSH conjugation of 4-hydroxynonenal and detoxifying lipid hydroperoxides via selenium-independent GSH peroxidase activity.
邹卫国研究组发现泛素连接酶SMURF2通过调节成骨细胞中维生素…
2017年2月21日 · smurf2是tgfβ信号途径的关键调节因子。 此研究表明,SMURF2能够通过调节SMAD3的泛素化,进而调节维生素D受体的信号途径,是TGFβ信号途径与维生素D信号途径发生串话的调节因子。
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 [Homo …
2025年1月5日 · Title: SMURF2 facilitates ubiquitin-mediated degradation of ID2 to attenuate lung cancer cell proliferation. E3 ubiquitin ligase SMURF2 prevents colorectal cancer by reducing the stability of the YY1 protein and inhibiting the SENP1/c-myc axis.
SMAD 特异性 E3 泛素蛋白连接酶 2(SMURF2)基因 | MCE
Enables SMAD binding activity; identical protein binding activity; and ubiquitin-protein transferase activity. Involved in negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of trophoblast cell migration; and ubiquitin-dependent SMAD protein catabolic process. Located in nuclear speck.
第四军医大学研究者们揭示了SMURF2促进泛素介导的ID2降解以 …
2023年8月28日 · Sci.杂志上发表了题为“SMURF2 facilitates ubiquitin-mediated degradation of ID2 to attenuate lung cancer cell proliferation”的文章,该研究揭示了SMURF2促进泛素介导的ID2降解以抑制肺癌细胞增殖。 Smad特异性E3泛素蛋白连接酶2 (SMURF2)在多种肿瘤中既可作为肿瘤促进剂,也可作为肿瘤抑制因子。 然而,SMURF2在非小细胞肺癌中的具体作用还不完全清楚。 本研究分析SMURF2的表达及其诊断价值。 研究者采用 免疫 共沉淀法 (Co-IP)、邻近连接试验 …