EMT是指具有极性的上皮细胞转换成为具有活动能力的间质细胞并获得侵袭和迁移能力的过程，最早被用于描述胚胎发育中某些特定部位的上皮细胞发生的形态学改变，如中胚层以及神经嵴的形成等。 它存在于人体多个生理和病理过程中。 肿瘤发生EMT时，上皮细胞表型发生可逆的改变，上皮细胞失去了细胞与细胞之间正常的结构，包括上皮细胞极性的丧失和间质特性（成纤维细胞样的外形、波形蛋白等基因的表达）的获得，细胞之间彼此分离，获得活动能力并抵抗凋亡。 最 …

Snail is a zinc-finger transcriptional repressor controlling EMT during embryogenesis and tumor progression. Through its N-terminal SNAG domain, Snail interacts with several corepressors and epigenetic remodeling complexes to repress specific target genes, such as …

其中研究最多的是Snail和Twist，早在2015年的一篇Nature论文中，通过基因敲除胰腺癌小鼠模型中的Twist和Snail之后，发现对于肿瘤细胞的转移几乎没有影响。

As a key transcriptional repressor of E-cadherin expression in EMT, Snail plays an important role in embryonic development and cancer progression. Emerging evidences indicate that Snail confers tumor cells with cancer stem cell-like traits, and promotes drug resistance, tumor recurrence and metastasis.

2025年1月16日 · 上皮间质转化（epithelial-mesenchymal transition，简称EMT）作为这一过程中的关键一环，不仅参与胚胎发育、伤口愈合等生理过程，更在器官纤维化和肿瘤转移等病理状态中发挥着至关重要的作用。

2023年3月7日 · SNAIL is a key transcriptional regulator in embryonic development and cancer. Its effects in physiology and disease are believed to be linked to its role as a master regulator of...

Snail not only acts primarily as a key inducer of EMT but also plays an important role in cell survival, immune regulation and stem cell biology. This review focuses on the regulation of Snail and discusses the EMT-dependent and -independent functions …

2022年4月22日 · 上皮 - 间质转化（EMT）是上皮肿瘤进展过程中发生的关键形态事件。 Snail 和 ZEB1/2（ZEB1 和 ZEB2）被称为 EMT 转录因子，是这一转变的关键调节因子。 ZEB1/2 与 EMT 表型和癌症的侵袭性呈正相关。 相反，Snail 也与癌症的侵袭性相关，但与 EMT 标记蛋白的表达无 …

2019年11月11日 · Here, the authors uncover a gene regulatory network between Prrx1 and Snail1 that selects EMT mode in developing vertebrates and cancer cells.

2014年8月2日 · Snail1 has a pivotal role in the regulation of epithelial-mesenchymal transition (EMT), the process by which epithelial cells acquire a migratory, mesenchymal phenotype, as a result of its repression of E-cadherin.