2016年3月28日 · We find that the ATP-dependent chromatin remodelling enzyme SNF2H plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding. At many other factor binding sites SNF2H and the related enzyme SNF2L contribute to nucleosome organisation.

iswi 复合体中的催化 atp 酶是 snf2l 或 snf2h，可将 1-3 个辅亚基组装成为 7 独特的复合体。 该家族的创始成员核小体重构因子 (NuRF) 含有 SNF2L，并且是发育期间基因激活所必需的。

2020年2月1日 · Here, we demonstrate that the ATP-dependent chromatin remodeling factor Snf2h (also known as Smarca5) plays a critical role in regulating meiotic cell cycle progression. Females with oocyte-specific depletion of Snf2h are infertile and oocytes lacking Snf2h fail to undergo meiotic resumption.

该论文报道了一种针对 SWI/SNF 染色质重塑复合物 ATP 酶 SMARCA2 和 SMARCA4 的蛋白水解靶向嵌合体降解剂，称为 AU-15330。

2023年5月12日 · 在结合文献报道基础上，该研究揭示了细胞内存在RPA-RNF20-SNF2H轴，发挥调控染色体分离和同源重组修复这两个生物学过程的双重作用。...

2014年6月20日 · Our studies reveal that Snf2h controls chromatin organization and histone H1 dynamics for the establishment of gene expression programs underlying cerebellar morphogenesis and neural maturation.

Here, we show that SNF2H, a member of the ATP-dependent chromatin-remodeling complex, is recruited onto DNA replication origins in human cells in a Cdt1-dependent manner and positively regulates MCM loading. SNF2H physically interacted with Cdt1. ChIP assays indicated that SNF2H associates with replication origins specifically during the G 1 phase.

2015年3月5日 · SNF2h is an ATP-dependent motor that enables nucleosome spacing by sensing flanking DNA length. Leonard and Narlikar show that nucleotide state regulates the position of the critical flanking DNA binding domain of SNF2h. They further find that this domain helps two motors avoid a tug-of-war.

2016年3月28日 · We find that the ATP-dependent chromatin remodelling enzyme SNF2H plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding. At many other factor binding sites SNF2H and the related enzyme SNF2L contribute to nucleosome organisation.

2023年1月10日 · The ISWI ATPase Smarca5 (Snf2h) is required for proliferation and differentiation of hematopoietic stem and progenitor cells