2016年2月26日 · Here we show that store-operated Ca 2+ entry (SOCE), mediated by the interaction between STIM1 (an endoplasmic reticulum Ca 2+ sensor) and Orai1 (a cell membrane pore structure), controls the...

Store-operated calcium entry (SOCE) is a ubiquitous Ca 2 + entry pathway that is activated in response to stimulation of plasma membrane receptors that are coupled to PIP 2 hydrolysis, IP 3 generation, and IP 3-mediated Ca 2 + release from the endoplasmic reticulum (ER).

This review focuses on recent advances made towards understanding the role of SOCE in immune cells with an emphasis on the immune dysregulation that results from defects in SOCE in human patients and transgenic mice. Keywords: Calcium, Ca 2+, ORAI1, STIM1, STIM2, CRAC, SOCE, T cell, Lymphocyte, Macrophage, Neutrophil, Immunodeficiency, SCID ...

2017年3月15日 · Here we show that deletion of Orai1 reduces, whereas deletion of Orai2 increases, SOCE in mouse T cells. These distinct effects are due to the ability of ORAI2 to form heteromeric channels with...

2023年12月26日 · Our findings unveil a direct crosstalk between SOCE and UPR via IRE1, acting as key regulator of ER Ca 2+ and proteostasis in T cells and muscles. Under ER stress, this IRE1-STIM1 axis boosts SOCE to preserve immune cell functions, a pathway that could be targeted for cancer immunotherapy.

2017年10月17日 · Store-operated Ca 2+ entry (SOCE) is the main Ca 2+ influx pathway in lymphocytes and is essential for T cell function and adaptive immunity. SOCE is mediated by Ca 2+ release-activated Ca 2+ (CRAC) channels that are activated by stromal interaction molecule (STIM) 1 and STIM2.

The store-operated calcium (Ca 2+ ) entry (SOCE) pathway is an essential Ca 2+ signaling pathway in non-excitable cells that serve many physiological functions. SOCE is mediated through the plasma membrane (PM) protein, Orai1, and the endoplasmic reticulum protein, stromal interac …

2019年7月15日 · Store-operated Ca 2+ entry (SOCE) is the predominant form of Ca 2+ entry in non-electrically excitable cells, and governs many critical cellular behaviors...

2016年10月5日 · Store-operated Ca2+ entry (SOCE) is the primary Ca2+ influx pathway in non-excitable cells. Long thought to be absent in nerve cells, neuronal SOCE is gaining popularity. We argue here that the evidence for SOCE in neurons remains contentious, mostly because SOCE imaging assays are inadequate in these cells.

2012年1月1日 · Calcium signals play a critical role in many cell-type specific effector functions during innate and adaptive immune responses. The predominant mechanism to raise intracellular (Ca²⁺) used by most immune cells is store-operated Ca²⁺ entry (SOCE), whereby the depletion of endoplasmic reticulum (ER) C …