Regulation of store-operated Ca2+ entry by IP3 receptors ... - eLife
2023年7月19日 · Convergent regulation by IP 3 Rs at two steps in the SOCE pathway may ensure that receptor-regulated PLC activity provides the most effective stimulus for SOCE; …
IP3 receptor isoforms differently regulate ER-mitochondrial contacts ...
2019年8月19日 · Using an IP3R-deficient cell model rescued with each of the three IP3R isoforms and an array of super-resolution and ultrastructural approaches we demonstrate that IP3Rs …
Arriving at the next level of complexity in IP3R and SOCE signaling
2023年11月1日 · A recent report describes the support of neuronal SOCE by IP 3 R1 based on a Ca 2+ transport-independent mechanism. IP 3 Rs are suggested to enable “optimal SOCE” …
Association of the IP3R to STIM1 provides a reduced ... - Nature
2018年9月5日 · Store-operated calcium entry (SOCE) is a conserved mechanism by which the depletion of the endoplasmic reticulum (ER) is conveyed to calcium-permeable channels at the...
将 IP3R 和 SOCE 信令的复杂度提升到一个新的水平,Cell Calcium
Hasan 实验室 [1] 最近的一份报告提供了证据，证明 IP3R1 在支持神经元中 STIM/Orai 介导的 SOCE 方面具有尚未被忽视的功能。 IP3R1 被证明可以通过由 IP3 触发但独立于受体作为 ER …
Regulation of store-operated Ca2+ entry by IP3 receptors
2023年7月19日 · Here, we demonstrate a novel mechanism by which the inositol 1,4,5 trisphosphate receptor (IP 3 R), an ER-localized IP 3-gated Ca 2+ channel, regulates neuronal …
IP3 receptors and Ca2+ entry - ScienceDirect
2019年7月1日 · IP 3 Rs are the usual means through which extracellular stimuli, through ER Ca 2+ release, stimulate SOCE. Here, we review evidence that the IP 3 Rs most likely to respond …
Regulation of store-operated Ca2+ entry by IP3 receptors …
2023年7月19日 · Loss of endoplasmic reticular (ER) Ca 2+ activates store-operated Ca 2+ entry (SOCE) by causing the ER localized Ca 2+ sensor STIM to unfurl domains that activate Orai …
IP3 受体对钙池操纵的 Ca2+ 进入的调节与其释放 Ca2+ 的能力无 …
在这里，我们展示了肌醇 1,4,5 三磷酸受体 (IP 3 R)（一种内质网定位的 IP 3门控 Ca 2+通道）调节神经元 SOCE 的新机制。 在人类神经元中，由 ER-Ca 2+药物消耗引起的 SOCE 会因 IP 3 …
Dual regulation of IP3 receptors by IP3 and PIP2 controls the ...
2024年10月3日 · IP 3-evoked Ca 2+ release triggers store-operated Ca 2+ entry (SOCE) by depleting the ER of Ca 2+, which causes the cytosolic domains of STIM to unfurl and stimulate …