Store Operated Calcium Entry - an overview - ScienceDirect
Store-operated calcium entry (SOCE) is a ubiquitous Ca 2 + entry pathway that is activated in response to stimulation of plasma membrane receptors that are coupled to PIP 2 hydrolysis, …
Pharmacology of Store-Operated Calcium Entry Channels
Today, our ability to pharmacologically dissect and manipulate the SOCE calcium signaling pathway remains a readily accessible way to understand receptor-regulated calcium signaling …
Store-Operated Ca²⁺ Entry (SOCE) Pathways - Springer
Describes the role of SOCE pathways in health and disease; Combines basic research with clinical aspects; The second edition was updated with new discoveries in the field of structural …
The STIM1-Orai1 pathway of store-operated Ca - Nature
2016年2月26日 · Store-operated Ca 2+ entry (SOCE) is a major Ca 2+ entry pathway in non-excitable cells, which involves several steps for activation, including (i)...
Unveiling some FDA-approved drugs as inhibitors of the store …
2017年10月16日 · The store-operated calcium entry (SOCE) pathway is an important route for generating cytosolic Ca 2+ signals that regulate a diverse array of biological...
Frontiers | Store-Operated Calcium Channels in Physiological and ...
2020年11月25日 · Store-operated calcium channels (SOCs) are widely expressed in excitatory and non-excitatory cells where they mediate significant store-operated calcium entry (SOCE), …
The ER stress sensor IRE1 interacts with STIM1 to promote store ...
2023年12月26日 · Our findings unveil a direct crosstalk between SOCE and UPR via IRE1, acting as key regulator of ER Ca 2+ and proteostasis in T cells and muscles. Under ER stress, this …
Store-Operated Ca2+ Entry Controls Clonal Expansion of T Cells …
2017年10月17日 · Store-operated Ca 2+ entry (SOCE) is the main Ca 2+ influx pathway in lymphocytes and is essential for T cell function and adaptive immunity. SOCE is mediated by …
Spatial localization of SOCE channels and its modulators regulate ...
2020年7月14日 · Although several Ca 2+ entry channels are present in neuronal cells, release of Ca 2+ from intracellular endoplasmic reticulum (ER) stores modulates store-operated Ca2+ …
CIF and other mysteries of the store-operated Ca2+-entry pathway
The molecular mechanism of the store-operated Ca2+-entry (SOCE) pathway remains one of the most intriguing and long lasting mysteries of Ca2+ signaling. The elusive calcium influx factor …