Superoxide dismutases (SODs) are universal enzymes of organisms that live in the presence of oxygen. They catalyze the conversion of superoxide into oxygen and hydrogen peroxide. Superoxide anions are the intended product of dedicated signaling enzymes as well as the byproduct of several metabolic processes including mitochondrial respiration.

2020年7月2日 · 活性氧自由基（reactive oxygen species，ROS）是氧气被部分还原（一分子氧气得到1个、2个或3个电子）的产物。 与氧气不同，ROS的活性非常高，几乎可以与任何物质反应。

2023年1月11日 · Nanozymes with superoxide dismutase (SOD)-like activity have attracted increasing interest due to their ability to scavenge superoxide anion, the origin of most reactive oxygen species in vivo.

2002年5月15日 · Within a cell, the superoxide dismutases (SODs) constitute the first line of defence against ROS. Specialization of function among the SODs may be due to a combination of the influence of subcellular location of the enzyme and upstream sequences in …

2024年2月22日 · 超氧化物歧化酶（sod）是生物体内的重要抗氧化酶，其主要功能是催化超氧阴离子（o2-）转化为过氧化氢（h2o2）和氧气（o2）。 在细胞内，超氧阴离子是一种具有高度活性的活性氧，可以攻击细胞膜和线粒体等细胞结构，导致细胞损伤。

Mitochondrial superoxide dismutase (SOD2) is a major component of the metabolic machinery that handles reactive oxygen species (ROS) in the mitochondrial matrix. Specifically, SOD2 determines how much superoxide radical anion (O 2 •−) is converted to hydrogen peroxide (H 2 O 2) (42, 90, 129) .

2023年8月20日 · sod可以通过调节活性氧（ros）的水平，影响多种信号通路，包括mapk、jak-stat和pi3k-akt等。例如，sod可以通过降低ros的水平，抑制mapk通路，从而抑制细胞增殖和诱导细胞凋亡。另一方面，sod可以通过清除ros，防止jak-stat信号通路的过度激活，从而调节免疫反应。

在生物体内物质正常代谢过程中可产生活性氧（Reactive oxygen species，ROS）活性氧包括单线态氧、超氧阴离子、过氧离子、自由基等，对大多数细胞都有毒性作用。

Regulation of sod genes plays a pivotal role in balancing the concentration of ROS. The compartmentalization and control of SODs at both expression and activity levels contribute to the level of SOD and consequent localized ROS level [21, 22]. This review focuses on recent progress made on sod gene regulation.

2018年6月4日 · Superoxide dismutases (SODs) are universal enzymes of organisms that live in the presence of oxygen. They catalyze the conversion of superoxide into oxygen and hydrogen peroxide. Superoxide anions are the intended product of dedicated signaling enzymes as well as the byproduct of several metabolic processes including mitochondrial respiration.