2012年4月1日 · The explanation of how are the lysosomal enzymes accurately recognized and selected over many other proteins in the trans-Golgi network relies on being tagged with a unique marker: the mannose-6-phosphate (M6P) group, which is added exclusively to the N-linked oligosaccharides of lysosomal soluble hydrolases, as they pass through the cis-Golgi ...

2024年11月25日 · These M6P-modified glycans are recognised by mannose 6-phosphate receptors that cycle between the Golgi and endosomes, diverting lysosomal hydrolases from the secretory pathway to their correct lysosomal destination.

经典的溶酶体定位标签是 甘露糖6-磷酸 （M6P）。 这需要蛋白质中具有特定序列（Asn-X-Ser / Thr），经内质网和高尔基体连续加工修饰产生。 M6P由甘露糖受体（MPR）识别。 MPR有两种类型（CD-MPR和CI-MPR），共同参与溶酶体蛋白的运输过程。 也有些蛋白通过非M6P-MPR依赖的途径靶向到溶酶体。 例如溶酶体整合膜蛋白（LIMP-II）负责运输溶酶体β-葡萄糖脑苷脂酶（β-GC）， Sortilin 可以转运神经降压素（NT），脂蛋白脂肪酶和鞘脂激活蛋白（ProSAP）等。 …

2003年3月1日 · The two mannose 6-phosphate (M6P) receptors were identified because of their ability to bind M6P-containing soluble acid hydrolases in the Golgi and transport them to the endosomal–lysosomal...

2014年7月14日 · The presence of M6P suggested to us that MPR might attach to LIMP-2 in order to transport β-GCase to the lysosome in a hetero-trimeric complex .

2022年9月12日 · Most enzymes utilize the mannose-6-phosphate (M6P) residues as a sorting signal for proper trafficking to the lysosome 1, 2. Because of its importance, the M6P biosynthetic pathway and its...

2023年7月18日 · The mannose 6-phosphate (M6P)-dependent pathway is the major route for lysosomal enzyme targeting in mammalian cells. Most newly synthesized lysosomal enzymes are tagged with M6P residues in the Golgi apparatus, which are recognized by M6P-specific receptors (MPRs) for subsequent transport to the lysosome (Figure 1A).

2024年1月1日 · In this review, we focus on the main roles and functions of the CI-M6PR, its implications in cancer, immunology, brain, and we highlight the studies strengthening the potential of the CI-M6PR as a target. Moreover, we will provide an overview of the cellular addressing of therapeutics through endocytosis mediated by CI-M6PR.

The ligand for the mammalian sorting receptors is mannose 6-phosphate (M6P). Two M6P receptors have been defined in mammals. Here, we review the foundational evidence supporting this mechanism and highlight the remaining gaps in our understanding of the mammalian mechanism, including evidence for M6P-independent sorting, and its relevance to ...

2025年3月6日 · 为探究甘露糖 - 6 - 磷酸（M6P）依赖的蛋白运输途径，研究人员发现新调节因子，为相关疾病治疗和研究提供方向。 在细胞这个微观世界里，溶酶体就像一个个勤劳的 “清道夫”，承担着分解和回收大分子物质的重任，维持着细胞内环境的稳定。 而溶酶体发挥功能，离不开 60 多种水解酶的帮忙，这些水解酶在合成后，需要经过一系列复杂的运输过程，才能准确抵达溶酶体 “上岗工作”。 其中，甘露糖 - 6 - 磷酸（M6P）依赖的蛋白运输途径起着关键作用。 在这个 …