In this review, we highlight the current knowledge on the regulation of Sost/sclerotin expression and its mechanism (s) of action, discuss novel observations regarding its role in signaling pathways activated by hormones and mechanical stimuli in bone, and propose future research needed to understand the full potential of therapeutic interventio...

Sclerostin is a protein that in humans is encoded by the SOST gene. [5] . It is a secreted glycoprotein with a C-terminal cysteine knot -like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists.

2020年10月23日 · First identified in patients suffering from sclerosteosis, SOST is a secreted glycoprotein that is predominantly expressed in osteocytes 6, 7. SOST inhibits new bone formation and growth by...

Sclerostin is a small protein expressed by the SOST gene in osteocytes, bone cells that respond to mechanical stress applied to the skeleton and appear to play an important role in the regulation of bone remodeling.

SOST can regulate osteoblastic differentiation and bone formation by binding type I/II receptors and co-receptor LRP5/6 to inhibit BMP and Wnt signaling pathways. Suppression of SOST provides a new approach for osteoporosis treatment.

2016年3月5日 · The SOST gene is located at 17q12-21, and codes for the protein sclerostin. Sclerostin is made primarily by osteocytes, and it inhibits bone formation and enhances apoptosis of osteoblasts. Patients with mutations in the SOST gene have very high bone density. SOST binds to LRP5 and inhibits the Wnt-signalling pathway. It is also a mild BMP ...

Both SOST gene and its synthetic protein, sclerostin, are hallmarks of osteocytes. According to our previous findings, blocking SOST induces bone formation and protects against bone loss and deformation caused by titanium (Ti) particles by activating the Wnt/β-catenin cascade.

2002年6月4日 · The diagnosis of a SOST-related sclerosing bone dysplasia is established in a proband with typical clinical and radiographic findings and biallelic pathogenic (or likely pathogenic) variants in SOST (in individuals with SOST-related sclerosteosis) or a biallelic 52-kb deletion downstream of SOST (in individuals with van Buchem disease ...

Sclerostin is a glycoprotein encoding by SOST gene and can bind to Lrp4/5/6 receptor to block the Wnt signaling pathway, so as to regulate the bone metabolism. Mutations of the SOST gene...

Sclerostin（SOST）主要在骨细胞中表达，是骨形成的负调节剂。 激素PTH和E2抑制SOST基因的表达。 转录因子Osterix，Runx2和Mef2c促进SOST表达，而Sirt1则负调控SOST表达。