Sclerostin is a protein that in humans is encoded by the SOST gene. [5] It is a secreted glycoprotein with a C-terminal cysteine knot -like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists.

2024年12月25日 · SOST (Sclerostin) is a Protein Coding gene. Diseases associated with SOST include Sclerosteosis 1 and Craniodiaphyseal Dysplasia, Autosomal Dominant. Among its related pathways are ncRNAs involved in Wnt signaling in hepatocellular carcinoma and Signaling by …

硬化蛋白(Sclerostin, SOST)主要由骨细胞特异性表达, 是骨形成的负性调节因子。甲状旁腺激素和雌激素抑制SOST基因表达, 转录因子Osterix、Runx2和Mef2c促进SOST基因表达, 而转录因子Sirt1负调控SOST表达。此外, SOST基因表达还受DNA甲基化和microRNA等表观遗传学调控。

2009年6月1日 · The SOST gene provides instructions for making the protein sclerostin. Sclerostin is produced in osteocytes, which are a type of bone cell. The main function of sclerostin is to stop (inhibit) bone formation.

Sclerostin (encoded by the SOST gene) is a potent antagonist of the canonical Wnt pathway and of bone formation, exerting its function by blocking LRP5/6 co-receptors [1,2]. To perform this function, sclerostin binds to LRP4, which enhances its suppressive effect [3,4,5].

2024年11月27日 · Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.

2002年6月4日 · The diagnosis of a SOST-related sclerosing bone dysplasia is established in a proband with typical clinical and radiographic findings and biallelic pathogenic variants in SOST (in individuals with SOST-related sclerosteosis) or a biallelic 52-kb deletion downstream of SOST (in individuals with van Buchem disease) identified on molecular genetic ...

Sclerostin, the product of the SOST gene, is a secreted inhibitor of Wnt signaling that is produced by osteocytes to regulate bone formation. While it is often considered an osteocyte-specific protein, SOST expression has been reported in numerous …

sost可以通过结合i / ii型受体和共受体lrp5 / 6来抑制bmp和wnt信号通路，从而调节成骨细胞的分化和骨形成。 SOST的抑制为骨质疏松症治疗提供了一种新方法。

Suppression of SOST provides a new approach for osteoporosis treatment. This review covers the structure, function and expression regulation of the SOST gene, human disease association, mechanism in the regulation of bone metabolism and prospect in clinical application.